Yann Ferrandez

About

Expertise: Research project, crystallography (X-Ray/SAXS), Protein-protein/DNA-protein interaction, Membrane protein, recombinant protein purification, Phage display

Experience

• École normale supérieure Paris-Saclay (11 yrs 6 mos)
  • researcher/engineer ENS Paris Saclay
    Nov 2018 - Present · 7 yrs 8 mos

    UMR 8113 CNRS LBPA Laboratoire de Biologie et Pharmacologie Appliquée 4 avenue des sciences 91190 GIF sur Yvette Cedex https://lbpa.ens-paris-saclay.fr/fr

  • PostDoctoral position in molecular biology and biochemistry
    Jan 2015 - Nov 2018 · 3 yrs 11 mos

    Biologie Structurale des Petites GTPases UMR 8113 CNRS LBPA Laboratoire de Biologie et Pharmacologie Appliquée bâtiment IDA pièce 206 61, avenue Président Wilson 94235 CACHAN Cedex http://www.lbpa.ens-cachan.fr/version-anglaise/teams/structural-biology-of-small-gtpases/

• PostDoctoral position in molecular biology and biochemistry at CNRS - Centre national de la recherche scientifique
  Nov 2013 - Dec 2014 · 1 yr 2 mos

  Small G proteins: Structures and Regulations Laboratoire d'Enzymologie et Biochimie Structurales LEBS-CNRS UPR 3082 Centre de Recherche de Gif 1, avenue de la Terrasse 91190 Gif sur Yvette France Publication : Vives V, Cres G , Richard C, Malaval L, Busson M, Ferrandez Y, Planson AG, Zehgouf M, Cherfils J and Blangy A. Disorganizing osteoclast podosomes through the pharmacological inhibition of Rac activation by Dock5 prevents osteolysis and preserves bone formation. Nat Com (accepted 2015)

• PostDoctoral position in molecular biology and biochemistry at Université Paris-Sud
  Sep 2012 - Sep 2013 · 1 yr 1 mo

  research project: Antibody and binder-assisted crystallogenesis of membrane proteins Publication : - Ferrandez Y1, Dezi M, Bosco M, Urvoas A, Valerio-Lepiniec M, Le Bon C, Giusti F, Broutin I, Durand G, Polidori A, Popot JL, Picard M, Minard P. Amphipol-mediated screening of molecular orthoses specific for membrane protein targets J Membr Biol. 2014 Oct;247(9-10):925-40 - Marie Valerio-Lepiniec, Agathe Urvoas, Anne Chevrel, Asma Guellouz, Yann Ferrandez, Agnès Mesneau, Ines Li de la Sierra-Gallay, Magali Aumont-Nicaise, Michel Desmadril, Herman van Tilbeurgh, Philippe Minard. The αRep artificial repeat protein scaffold: a new tool for crystallization and live cell applications. Biochemical Society Transactions Oct 09, 2015, 43 (5) 819-824.

• PostDoctoral position in molecular biology and biochemistry at Ecole Nationale Vétérinaire d'Alfort
  Jan 2011 - Jan 2012 · 1 yr 1 mo

  Research Project: Role of "Heme Binding Protein" in the vectorization and virulence of Bartonella. Director: F. Biville Publication: Ferrandez Y., Bouhsira E. , Liu M., Franc M., Boulouis HJ. , and Biville F. Ctenocephalides felis an in vitro potential vector for five Bartonella species. Comp Immunol Microbiol Infect Dis. 2012 Nov 28 Liu M., Ferrandez Y., Bouhsira E. , Monteil M., Franc M., Boulouis HJ. , and Biville F. Deciphering the roles of Heme binding proteins family of Bartonella henselae. PLoS One. 2012;7(10) UMR BIPAR (http://www.vet-alfort.fr/web/fr/465-umr-956-inra-afssa-paris-xii-enva-biologie-moleculaire-et-immunologie-parasitaires-et-fongiques.php) ANSES/ENVA of Maison Alfort Sector: Research and development

• PostDoctoral position in molecular biology and biochemistry at CNRS ; French National Center for Scientific Research
  Sep 2009 - Sep 2010 · 1 yr 1 mo

  research project: Dynamic assembly of efflux pump in a biomimetic bilayer Director: Isabelle Broutin /Arnaud Ducruix publication: Ferrandez Y., Monlezun L., Phan G., Benabdelhak H., Benas P., Ulryck N., Falson P., Ducruix A., Picard M. and Broutin I. (apr 2012) Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis. Electrophoresis. 33(8):1282-7 Team "Pompes à efflux" (http://lcrbw.pharmacie.univ-paris5.fr/spip.php?rubrique8) UMR 8015 Cristallographie & RMN, Université ParisDescartes, Paris, France Director : F. Dardelle/A. Ducruix, Sector : Research and development