Xinyi Li

Senior Director of Biology | Drug Discovery | Autoimmune Disease | Immunology | Translational Medicine | Clinical Development | Biomarker | Targeted Protein Degradation | Oncology | Neurodegeneration

San Diego Metropolitan Area

About

Achiever | Project Leader | People Manager | Team Player | Innovator | Passionate Drug Hunter Immunology | Autoimmune Disease | Neurodegeneration | Targeted Protein Degradation | Antibody Discovery - Strong Background in Statistics (Ms degree) - Broad Experience in Drug Discovery: small & Large molecule, Peptide, Targeted Protein Degradation - New Target Identification, Evaluate External Assets and New Indications, Help Build Industry Leading Pipelines - Lead early-to-late stage drug discovery projects in Autoimmune Diseases and Neurodegeneration - Support clinical development, Translational Science, Biomarkers, and Draft regulatory files (IND, IB…) - Expertise in Assay Development, Molecular Biology and Biochemistry - Track-of-Record of Accomplishment (Succssful Drugs, Projects, Manuscripts, Patents) - People First Manager

Experience

  • RayThera (Full-time · 2 yrs)
    • Senior Director of Biology
      Apr 2026 - Present · 4 mos

      Immunology Discovery, Autoimmune diseases, Translational Medicine, Oncology Discovery Small molecules and Induced proximity Drug discovery Project lead from early discovery to IND filing

    • Director of Biology
      Aug 2024 - Apr 2026 · 1 yr 9 mos

  • Takeda (Full-time · 4 yrs 1 mo)
    • Associate Director, GI Inflammation, Autoimmune disease
      Aug 2022 - Aug 2024 · 2 yrs 1 mo

      Project lead / Early Drug Discovery to IND filing Support clinal development / nonclinical in vitro Pharmacology / Translational Science / Biomarkers Help build competitive pipeline / Target Identification / External Asset Evaluation Small molecule and biologics

    • Principal Scientist, project lead
      Jan 2022 - Sep 2022 · 9 mos

      Cell Assay Development / molecular biology / protein chemistry / Targeted Protein Degradation / Immunology

    • Senior Scientist, Project Lead
      Aug 2020 - Jan 2022 · 1 yr 6 mos

  • The Janssen Pharmaceutical Companies of Johnson & Johnson (5 yrs 8 mos)
    • Scientist, Immunology Discovery
      Mar 2018 - Aug 2020 · 2 yrs 6 mos

      Drug Discovery: Significant contribution to development of two of clinical trial assets in Autoimmune Diseases : ICOTYDE™ (icotrokinra) approved by FDA in March 2026

    • Scientist, Project Leader
      Jan 2015 - Mar 2018 · 3 yrs 3 mos

      Antibody Discovery: Led a complex single cell based antibody discovery projects with teams across global sites Assay development, Molecular Biology, Protein chemistry, Neurodegeneative diseases

  • Postdoctoral Researcher at The Scripps Research Institute
    Aug 2008 - Jan 2015 · 6 yrs 6 mos

    Protein aggregation | Neurodegeneratoin | Amyloidosis

  • Postdoctoral Researcher at Case Western Reserve University
    Aug 2006 - Jul 2008 · 2 yrs