San Diego, California, United States
I have extensive experience in preclinical models of central nervous system diseases, with a solid foundation in cellular biology, electrophysiology, and next-generation sequencing. My research interests focus on neuro-glial interactions and their roles in the pathomechanisms of neurodevelopmental and neuropsychiatric disorders.
• Demonstrated the roles of Trem2 hypofunction in neural network abnormalities and cognitive deficits in Alzheimer’s disease-related mouse models • Established protocols for cell and nuclei sorting for single-cell/bulk RNA-seq and ATAC-seq from mouse brain • Designed and executed a preclinical evaluation of antiepileptic drugs for the treatment of Alzheimer’s disease-related brain dysfunctions • Implemented novel application of DNA damage in situ ligation followed by proximity ligation assay in postmortem samples to demonstrate accumulation of DNA double-strand breaks in vulnerable neurons early in Alzheimer’s disease
• Combined RNA-seq, ChIP-seq, and electrophysiology approaches to uncover novel functions of epigenetic regulator L3mbtl1 in homeostatic synaptic plasticity • Identified the role of the autism-related gene Shank1 in maintaining excitatory and inhibitory balance by employing patch-clamp and quantitative confocal imaging