Constance, Baden-Württemberg, Germany
Computer System Validation expert that combines extensive bioinformatics and molecular biology expertise with excellent communication skills. Equally experienced in project- and line-management. Enjoys working with multi-disciplinary teams and to facilitate close interaction between different disciplines such as molecular biology and IT. Skills: CSV Expert, Validation Plan, Risk Assessment, URS, OQ, PQ, GxP, Lab Instrument Qualification, Project Management, Audit, Annex 11, GAMP 5, 21 CFR Part 11, Data Integrity, ALCOA+, Quality Risk Management, Change Management Qualifications: Certified Chromeleon administrator Certified LabWare LIMS administrator Trained MODA administrator ECA Certified Computer Validation Manager ECA Certified Data Integrity Manager
- Manage Illumina HiSeq 2500 and 4000, MiSeq, PacBio RS II and Roche GS FLX NGS projects - Provide data analysis for genome re-sequencing, targeted re-sequencing, de-novo sequencing, RNA-Seq and special applications
- Product development for cytogenetics, molecular genetics and cancer diagnostics - Guiding development of commercial software applications - Statistical data analysis of microarray data and NGS data - Project management of internal, external and collaborative studies - Biomarker Discovery
Development of several OGT products including the CytoSure SyndromePlus microarray for cytogenetics and the CytoSure DMD array for molecular genetics. Conception and implementation of the OligomeTM, a resource enabling OGT to offer bespoke gene expression, methylation and aCGH microarray designs.
Project analysis, project management and a substantial part of the actual scientific and technical implementation of several core components of the PharmaCartaTM Chemogenomics platform. ORACLE database design and GUI implementation of DrugStore and StARlite. These databases link chemical, biological and medicinal data and are now being hosted by ChEMBL at the EBI.
Development of numerous tools for sequence annotation and microarray data analysis for target discovery. Key contributions to a patent application. In my function as line manager of 3 bioinformaticians I had to co-ordinate our efforts with the global bioinformatics core group in Hayward, USA.