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My research focuses on engineering drug delivery at biological interfaces, with particular emphasis on controlling how pharmaceutical materials retain at, penetrate through, and deliver across mucosal and other biological barriers. A major theme of my work is the design of polymeric and nanomaterial-based systems for mucosal and topical drug delivery, including mucoadhesive materials, mucus-penetrating nanoparticles, hydrogels, polymer complexes and functional biomaterials. I am also developing predictive approaches for formulation evaluation, combining biomimetic and ex vivo models with invertebrate systems to assess retention, biological activity and safety while supporting the development of alternatives to conventional animal experimentation. Core areas of expertise: • Mucoadhesion and mucosal drug delivery • Mucus penetration and nanoparticle–barrier interactions • Ocular, nasal, oromucosal, gastrointestinal and vaginal drug delivery • Pharmaceutical polymers, hydrogels and biomaterials • Water-soluble, amphiphilic and stimuli-responsive polymers • Polymeric complexes and functionalised polymers • Polymeric, silica and metal nanoparticles • Predictive formulation science, ex vivo testing and invertebrate models
Developing oxidation-responsive nanomaterials
Developing hydrophobically-modified polysaccharides as pharmaceutical excipients for improving solubility of poorly-soluble drugs