Amsterdam, North Holland, Netherlands
- Involvement in projects ranging from early R&D to pre-clinical and phase I trials - Adapt quickly to work in different disease areas - Development of biomarker assays - Creative and resourceful personality with organizational skills • keywords: clinical science; biomarkers; predictive markers; infectious diseases, antibody therapy, vaccines; assay development & technology solutions; antivirals; protein engineering; biomarker identification; mode of action studies; high throughput screening; automation; clinical immunology; microscopy; high content imaging; big data visualization; big data analytics; R programming; team leader.
Exploration and design of high throughput and proof of concept assays for disease markers. Supervision of internal and external lab explorations on assays and technologies, supporting outsourcing decisions and CRO management. • Biomarker discovery • Data analysis and visualization using R
Managing the development of diagnostic assays for Alzheimers Disease • Assay development • Biomarker discovery • Automation • Miniaturization • Data analysis and visualization using R
Antibody Discovery and Characterization (Infectious Diseases) & Development of bio-assays • Lead a team of technicians • Characterization of antivirals/monoclonal antibodies (lead molecules) • Mechanism of action studies, cell-based infection assays, biochemical/enzymatic assays. • (Bio-) assay development for non-clinical characterization of lead molecules • Setup bio-marker assays for clinical trials • Contributed data to successful IND filings and up to phase II clinical trials
Discovery antiviral molecules to fight infectious diseases • Screening antibodies, peptides, and small molecules for virus neutralization activity • Mechanism of action studies in cell-models. • Live cell imaging and tracking of virus (laser scanning confocal imaging) • Characterization of broadly neutralizing antibodies against human pathogens such as Influenza and HCV • Development of cell- and imaging-based assays • Design and test virus production platforms (Polio and Influenza)
• Head of cell culture division of 7 technicians • Management and design experiments • Transfection and clone generation to establish eukaryotic transgene expression platforms • Test novel genetic repression blocker elements for transgene expression
Research of autoimmune ocular pathology • Analysis of intra-ocular cytokine responses in rats after induced uveitis • T cell receptor analysis of synovial T cells of HLA-B27 positive RA patients