South San Francisco, California, United States
In the laboratories of Dr. Amander Clark and Dr. Kathrin Plath we were working on X chromosome dynamics during human early embryonic development. Using single cell technologies together with microscopy we have dissected molecular mechanisms of sex specific differences taking place during human germline formation.
Teaching assistant of upper division class - Developmental Biology
Teaching assistant for upper division class - Molecular Biology of Cellular Processes.
As a Master student in Prof. Heinrich Leonhardt's lab we have employed 3D-SIM Super Resolution imaging to investigate the role of repeat elements of lncRNA Xist in silencing X-linked genes. Using this approach we have visualized, quantified and analyzed Xist molecules in wild type and and mutant cell lines lacking repeat elements in the Xist transcript. Ultimately this work has contributed to the Nature paper: "A protein assembly mediates Xist localization and gene silencing".
Teaching assistant for Bio-imaging practical course for 2nd year Master students.
In Leonhardt lab, I have worked to develop CRISPR based targeted gene silencing tools
I worked on my Bachelor Thesis with Prof. Frank Schnorrer's lab investigating the role of Dlg5 in Drosophila flight muscle development. Using RNAi crosses we have shown that Dlg5 plays essential role in flight muscle development and ultimately its knockdown results in lethality during pupal development.