London, England, United Kingdom
I am a Consultant Hepatologist and Principal Investigator at the Roger Williams Institute of Liver Studies, King’s College London, where I lead a research programme focused on liver metabolism and circadian biology. My work focuses on experimental medicine and translational research in steatotic liver disease, including MASLD, MetALD and alcohol-related liver disease. I am particularly interested in how circadian biology regulates liver metabolism and how disruption of biological timing contributes to metabolic dysfunction and liver disease progression. I lead mechanistic human studies that combine deep metabolic phenotyping, advanced imaging, and interventional approaches to better understand disease pathways and identify novel therapeutic targets. This includes the use of hyperinsulinaemic–euglycaemic clamp studies, stable isotope methodologies, multi-tissue sampling, and liver–brain imaging. A central aim of my work is to translate mechanistic insights into clinical interventions, including targeting metabolic and circadian pathways in patients and at-risk populations such as shift workers. I welcome collaborations across academia, industry, and clinical research to develop and test innovative approaches to treating metabolic liver disease.
Roger Williams Institute of Liver Studies
DPhil in Biomedical and Clinical Sciences Circadian rhythms and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach,