The Randstad, Netherlands
Department of Hematology Advisor: Professor Dr. Ivo Touw - Investigating the role of RUNX1 and G-CSFR mutations in the development of acute myeloid leukemia using in vitro and in vivo model systems
Laboratory of Experimental Oncology, Department of Surgery Advisor: Professor Dr. Inne Borel Rinkes and Professor Dr. Onno Kranenburg – Identifying cKIT-SCF signaling as a novel mechanism that promotes EMT in colorectal cancer – Studying the effect of cKIT inhibition on EMT and tumor initiation – Developing co-cultures to study epithelial-mesenchymal transition (EMT) in colorectal cancer – Establishing spheroid and organoid cultures from primary colorectal tumors
Department of Hematology – Identifying novel STAT5 target genes in hematopoietic stem and progenitor cells that are involved in STAT5 induced stem cell self-renewal and long-term expansion – Studying the oncogenic KRAS induced phenotypes and signaling pathways in hematopoietic cells and identifying angiopoietin-like 6 as an important secreted factor that enhances proliferation in human CD34+ cord blood cells