Cracow Metropolitan Area
-Target deconvolution -Screening cascade design -Introduction and optimization of the assays enabling comprehensive compound characterization -Leading role in strategy for screening of potency, selectivity and efficacy -Leading role in biomarker strategy - selection, development and qualification of methods -Design and supervision of in vivo experiments allowing to provide in vivo proof of concept for tested compounds -Proposing and leading activities around MoA and responder hypothesis -Evaluation and interpretation of the experimental results of pre-clinical studies -Support of pre-clinical activities -Participation in development and qualification of clinical biomarkers
• Worked with experimental models of kidney and cardiovascular diseases such as hypertension, high fat diet-induced obesity, renal ischemia-reperfusion injury, abdominal aortic aneurysm formation. • Identified and evaluated novel targets of therapeutic intervention in cardiovascular disease • Prepared reports, posters and scientific publications • Trained new students
• Prepared theoretically and experimentally to conduct studies related to mechanism of signal transduction as well as gene expression regulation • Performed cloning and studied expression and DNA- binding activity of IRF transcription factors and their possible interaction with STAT1 and STAT2 in IFN signalling • Managed laboratory functions (organization, ordering and scheduling equipment use) • Trained new students