Los Angeles Metropolitan Area
- Antibody and peptide engineering for BNCT and ADC applications - Fc engineering to modulate effector functions, facilitate site-specific conjugation and improve safety/drug efficacy - In vitro/in vivo phage display to identify novel tumor-targeting agents - Development of blood-brain-barrier crossing agents
-Bi-specific & Tri-specific antibody design and development -Antibody humanization and engineering
-Identification of genetic and cell culture parameters affecting glycosylation patterns, effector functions and pharmacokinetics of therapeutic antibodies - Multi-omics and NGS analyses for target identification, validation and application; -Developability assessment and cell line engineering for therapeutic recombinant proteins; -Cell culture media and process optimization; -Drug substance and drug product manufacturing optimization
-Oncogenic mutation and signaling pathway analyses; -Protein engineering to modulate oncogenic activity