Siva Sankar Mahamkali

Heading large scale commercial manufacturing sites for the supply of drug substance (DS) and drug product (DP) Biosimilar mAbs.

Greater Bengaluru Area

About

25 years of Biologics operations experience. Managed many Biopharmaceutical products manufacturing, scale-up, technology transfer in CDMO and commercial manufacturing setup. Played a big role in EMA and USFDA inspections. Built and operated 3 cost effective Biologics (Single use, hybrid and SS) manufacturing facilities with state-of-the-art design and global compliance standards. My core specialties in Biologics: DS Manufacturing and fill finish - Biosimilar mAbs, novel mAbs and ADCs Facility design, Commissioning & Qualification Creating business and implementation cases P&Lmanagement Business strategy People management

Experience

  • Vice President - Biosimilars Manufacturing operations at Reliance Lifesciences
    Apr 2026 - Present · 3 mos

  • Senior Director at Aragen Biologics pvt Ltd
    Oct 2025 - Apr 2026 · 7 mos

  • Director- Aragen life sciences pvt Ltd at Aragen Life Sciences
    Nov 2022 - Dec 2025 · 3 yrs 2 mos

  • Syngene International Limited (12 yrs 11 mos)
    • Plant Head -Biopharmaceutical Manufacturing Operations
      Jul 2016 - Nov 2022 · 6 yrs 5 mos

      Leading Scale-up and GMP manufacturing (contract) operations for the Mabs and various key Biosimilar proteins ( An EU GMP certified facility of Syngene Biologics ). worked on multiple 2 KL single use platform based operations for manufacturing of mAbs. Established scale-up and technology transfer cell culture process. Played a key role in EU-GMP and USFDA approval for the Biologics manufacturing plants. Business case development and building cost effective manufacturing plant and labs to support the Biologics business expansion. Client engagement and collaboration. Team building and talent management.

    • Associate Scientific Manager
      Jan 2010 - Jul 2016 · 6 yrs 7 mos

      Mammalian and microbial manufacturing operations.

  • Senior Scientist - Biopharma R&D Centre at Panacea Biotec Ltd
    Aug 2007 - Jan 2010 · 2 yrs 6 mos

    Worked on the Biosimilar Mabs and glycoproteins (cell culture -USP) process development and process optimization. Worked on micro carrier based viral vaccine development (Bio safety level -3). Introduced and used disposable Biotreactor technology (SUB) for the process development. Worked on Tox requirements and facilitated the Tox material.