Bern, Berne, Switzerland
• Development and validation of analytical methods in compliance with ICH and pharmacopoeia requirements • Led analytical investigations/studies and troubleshooting activities to resolve QC issues and improve method robustness • Design and execute analytical studies to support method performance • Scientific exchange and alignment with external partners on outsourced analytical methods • Support routine QC analytical testing (troubleshooting) • Author technical reports summarizing analytical experiments • Mentoring of apprentices during practical training
• Reviewed and approved analytical results across multiple techniques to support batch release • Responsible for implementation and validation of analytical methods for new products • Led troubleshooting of failed analytical experiments • Managed deviations, change controls, and CAPAs in compliance with GMP requirements • Authored and reviewed analytical procedures and documentation
• Development of peptide- and protein-based therapeutics, including evaluation of biological activity (e.g. protease-inhibition assays) targeting proteins of the blood coagulation pathway • Protein expression, protein purification and characterization using bioanalytical techniques (SDS-PAGE, HPLC, IEX, UV-Vis spectroscopy, MS-analysis)
• Research on GABAA receptors and the benzodiazepine binding site • Identification of new high-affinity ligands of the benzodiazepine binding site • Determination of the biological activity of small molecules identified in screening assays