Shenzhen, Guangdong, China
My research focuses on decoding and engineering immune cell functional states across development, tissue microenvironments, and disease, using integrated single-cell and spatial multi-omic approaches. By combining high-resolution cellular profiling with rational perturbation and state reprogramming strategies, my lab aims to uncover regulatory principles that govern immune adaptability and translate them into designable and controllable immune interventions.
•Establishing an independent basic research program in single-cell systems immunology, aimed at understanding and experimentally testing the regulatory logic of immune cell states across development and tissue contexts. •Developing a clinically collaborative translational program that integrates patient-derived single-cell and spatial profiling with design-oriented perturbation frameworks, enabling state-informed immune modulation in human disease.
•Established an integrated experimental–computational pipeline for single-cell multi-omics in clinical cohorts, enabling cell-state discovery and therapeutic target identification across autoimmune and fibrotic diseases, including systemic sclerosis and psoriatic arthritis (Science Immunology 2025; Cell 2022). •Constructed spatiotemporal immune atlases across prenatal development, defining tissue-resident macrophage states and neuroimmune crosstalk (Cell 2025; 2023).
•Led translational single-cell studies integrating drug-response phenotyping, uncovering novel resistance pathways and therapeutic targets in multiple myeloma (Nature Medicine, 2018; 2021). •Performed multi-tissue single-cell profiling of NK cells and ILC1s, defining circulating versus tissue-resident transcriptional programs and revealing tumor-induced reprogramming of innate lymphocytes (Immunity 2021).
Conducted research on gene regulation and epigenetic control of chromatin architecture in innate immune cells and during early embryonic stem cell differentiation.
•Co-led a seminal study on trained immunity, demonstrating that β-glucan epigenetically reverses LPS-induced immune tolerance and establishes a mechanistic basis for innate immune memory (Cell 2016). •Contributed to the EU BLUEPRINT consortium, profiling immune cell epigenomes and co-authoring multiple studies in Cell and other Cell Press journals. •Co-developed Capture Hi-C, a high-throughput chromatin interaction mapping technology, uncovering ultra–long-range chromatin interactions at Hox loci and their roles in ground-state versus primed pluripotency (Cell Stem Cell 2015).