San Mateo, California, United States
Accomplished biotechnology scientist with extensive industry experience and strong track record of developing and supporting innovative products for academic and pharmaceutical research. Demonstrated strong synthetic and analytical chemistry background for discovery and development of new products in a multidisciplinary team environment. An extensive background in organic chemistry with emphasis on nucleosides/nucleotides, oligonucleotides, Glycans, and fluorescent dyes. Track record of scientific accomplishments as reflected by 33 issued US patents, 37 publications in peer reviewed international journals, 3 book chapters, 1 book and many presentations at meetings/conferences. Exceptional adaptability, diversity, innovation and creativity. Possesses excellent oral, written communication skills, interpersonal skills. Specialties: Nucleosides, Nucleotides, Oligonucleotides, Glycans, Bioconjugation, Dyes, DNA Sequencing Chemistry, Glycan Analysis, Capillary Electrophoresis, Chromatography-HPLC/UPLC, Fluorescence Chemistry and Detection, Reagent and Instrument Integration, Intellectual Property Management, Design of Experiments, Organic Synthesis, Structure-activity relationship (SAR), People Management.
• Developed reagents for semiconductor DNA sequencing • Developed methods for polymer particles bioconjugation
• Developed methods for bioconjugation of small molecules to nucleotides and oligos • Conducted labeling chemistry for the Supported Oligonucleotide and Ligation DNA (SOLiD) sequencing probes • Designed and executed multistep synthesis and performed large scale synthesis of novel fluorescent labeled nucleotide-triphosphates (dNTP, ddNTP) and primers/oligos for DNA sequencing, PCR, genotyping and other applications • Designed and synthesized nucleotide analogs as terminators/reversible terminators for DNA sequencing • Developed dye-terminator matrix for sequencing chemistry (d-Rhodamine, BigDyeTM version 1-3) • Partnered with biochemists, manufacturing, and marketing personnel to commercialize sequencing reagents • Developed dye-terminator (rNTP) matrix for direct PCR sequencing chemistry • Conceived and developed reagents for size-standards used in DNA sequencing, Genotyping and other applications • Developed methods for reducing-end derivatization of glycans for analysis of glycoprotein derived oligosaccharides • Developed analytical methods for analysis of glycans by capillary electrophoresis and HPLC