Menlo Park, California, United States
Experienced, hands-on scientist/engineer interested in opportunities that push science and technology to the next level and positively impact human health. Education: Ph.D. Molecular Biology and B.S. Electrical Engineering. Specializing in nucleic acid chemistry, biophysics, molecular biology, electrochemistry, and microfluidic chip design. Recent experience with nanopore technologies, surface-based isothermal DNA amplification, modified nucleotides for electronic DNA sequencing, DNA polymerase engineering, and single molecule detection. Past experience with RNA structure probing, protein—RNA, and small molecule—RNA interactions. SPECIFIC SKILLS: Molecular Biology, DNA and Protein Sequencing: ONT Nanopore technology, sequencing by synthesis chemistries and detection methods, NGS library preparation, nucleic acid sample prep, DNA amplification (PCR and isothermal), nucleic acid structure and biophysics, modified nucleotides and oligonucleotides, RNA structure probing, and numerous molecular cloning and biochemistry methods (too many to list). Familiarity with Unix command line and Python programming. Engineering: Microfluidic chip design, fabrication, and testing. 3D CAD with Solidworks, multiphysics FEA with COMSOL, circuit simulation with SPICE, LabView for breadboard control. Familiarity with silicon, polymer, and elastomer microfabrication technologies. Familiarity with impedance spectroscopy, and other electrochemical methods. Past experience with MOSFET device physics and CMOS circuit design.
Participated in the development of Glyphic's protein sequencing by expansion technology, using nanopore readout.
Developing novel DNA, RNA, and protein sequencing tools.
Nexgen Biotools is solving the library prep bottleneck in nextgen sequencing workflows with novel microfluidics solutions.
Responsible for developing the next iteration of Ultima's clonal amplification technology.
Worked mainly on adapting Roswell's single-molecule detection technology for DNA sequencing applications.