Hong Kong, Hong Kong SAR
Obtain: FDA orphan drug designation of progressive familial intrahepatic cholestasis (PFIC); 19 November 2024; https://www.innorna.com/news/336.html FDA RPD designation of progressive familial intrahepatic cholestasis (PFIC); 1 November 2024; https://www.innorna.com/news/326.html FDA orphan drug designation of Progressive Familial Intrahepatic Cholestasis (PFIC); 30 July 2024; https://www.innorna.com/news/322.html FDA orphan drug designation of classic homocystinuria (HCU); 19 July 2024; https://www.innorna.com/news/311.html FDA RPD designation of Progressive Familial Intrahepatic Cholestasis (PFIC); 10 July 2024; https://www.innorna.com/news/307.html FDA RPD designation of classic homocystinuria (HCU), a serious or life-threatening genetic disease ; l5 July 2024; https://www.innorna.com/news/301.html Previous publications: Loh, Jia Jian; Ng, Kai Yu; Huang, Ianto Bosheng; Deng, Mingdan; Wang, Yanyan; Man, Ki Fong; Lam, Ka Hei; Lee, Terence Kin-Wah; Tan, Jia Yan; Cui, Yalu; Yu, Huajian; Wong, Tin Lok; Gao, Yuan; Yun, Jing-Ping; Ma, Stephanie. DGKH-mediated phosphatidic acid oncometabolism as a driver of self-renewal and therapy resistance in HCC. Hepatology ():10.1097/HEP.0000000000001158, November 12, 2024. Min-Yue Zhang; George Calin; Ming-Dan Deng; Rex K. H. Au-Yeung; Lu-Qian Wang; Chor-Sang Chim. Epigenetic Silencing of Tumor Suppressor lncRNA NKILA: Implication on NF-κB Signaling in Non-Hodgkin’s Lymphoma. Genes 2022, 13, 128 . Mingdan Deng; Wei Dai; Valen Zhuoyou Yu; Lihua Tao; Maria Li Lung. Cylindromatosis Lysine 63 Deubiquitinase (CYLD) Regulates NF-kB Signaling Pathway and Modulates Fibroblast and Endothelial Cells Recruitment in Nasopharyngeal Carcinoma. Cancers 2020, 12, 1924 . Hong Zheng; Wei Dai; Arthur Kwok Leung Cheung; Josephine Mun Yee Ko; Rebecca Kan; Bonnie Wing Yan Wong; Merrin Man Long Leong; Mingdan Deng; Tommy Chin Tung Kwok; Jimmy Yu-Wai Chan; Dora Lai-Wan Kwong; Anne Wing-Mui Lee; Wai Tong Ng; Roger Kai Cheong Ngan; Chun Chung Yau; Stewart Tung; Victor Ho-Fun Lee; Ka-On Lam; Chung Kong Kwan; Wing Sum Li; Stephen Yau; Kwok-Wah Chan; Maria Li Lung. Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma. Proceedings of the National Academy of Sciences of the United States of America 2016, 113, 11283 -11288.
I am working as a project leader on mRNA drug discovery and development to treat some diseases safely and efficiently.
Researches on leukemia and liver cancer. Exploring target genes function in tumor development and microenvironment. Also established organoid culturing for primary mouse tumor cells.