James R.

Translational Immunologist & Drug Developer | Biotech Founder, Executive, Advisor and Operator |

Switzerland

About

• Drug developer with 20+ years’ experience translating immunology into therapeutics across multiple modalities and indications, from target discovery/validation through to Phase 2 proof-of-concept (e.g. anti‑CD40 mAb Iscalimab in transplantation and autoimmune diseases). • Biotech company creator and C‑level operator (CEO, CSO, CDO, Co‑founder, EIR) with a track record of building teams and platforms, de‑risking development candidates to IMPD, and leading successful financings. • Strategic portfolio and commercial thinker with dual scientific and business training who has led new product strategy, indication and asset prioritization, TPP design, and early commercial planning in a major pharma (Novartis) and multiple biotechs. • Cross‑ecosystem operator at the Biotech–VC–Pharma interface, providing due diligence and company-building input as a Venture Partner, Investment Committee member and advisor to multiple funds and portfolio companies, while maintaining deep engagement with BD&L, Health Authority interactions, CROs/CDMOs, scientific and clinical KOLs as well as commercial experts. • Leader of high‑performing translational and computational biology organizations (up to ~40 FTE) known for integrating AI/ML and human multi‑omics into early R&D, and for empathetic, hands‑on mentoring that enables scientists and executives to execute efficiently from concept to clinic and toward value‑creating exits.

Experience

  • Managing Director at Triangulate GmbH
    Jan 2023 - Present · 3 yrs 6 mos

    Active SAB member for PsiThera Therapeutics, Adoram Therapeutics, Calluna Pharmaceuticals

  • 66ten Investment Committee Member at WEHI (Walter and Eliza Hall Institute of Medical Research)
    Aug 2023 - Present · 2 yrs 11 mos

  • Scientific Advisor at Psithera Therapeutics
    Jun 2024 - Present · 2 yrs 1 mo

  • Scientific Advisor at Adoram Therapeutics
    May 2024 - Present · 2 yrs 2 mos

  • Chief Executive Officer at Spica Therapeutics
    Sep 2024 - May 2026 · 1 yr 9 mos