’s-Hertogenbosch, North Brabant, Netherlands
All-round Senior Lab. Technician with experience in chemical engineering and specialized in process safety. With an eye for detail and focused on sustainability, I develop cost-efficient chemical process routes in a creative way. This involves feasibility studies in the laboratory, optimization and scaling up to introduction and supervision in the (chemical) plant. I am a social, committed, reliable and honest person who cannot sit still. A structured go-getter who is open to apply his knowledge in other sectors.
• New Product Development and CDMO projects • Developing & Improving production processes (lab research) • laboratory feasibility studies (Lab research) • Optimization (Lab research incl. automated lab reactors) • Development phase (Lab -> production) - Tech. Transfer of lab protocol to production protocol - Supervising first production development batches - Direct Trouble shooting - Direct Root Cause Analysis (RCA) - Deviation Management - Optimization of lab protocol (on the basis of post-production development batch results) for upcoming Process Performance Qualification (PPQ) & Process Control strategy • Fate and Purge studies (Lab: - mapping purity profile of the pharmaceutical ingredients (API), - identification, clarification and determine purging behavior of byproducts in raw material and API • Critical parameter research
• Writing & updating digital Work Lists (PCS) for production processes (Pharma) • Supervising production processes • Troubleshooting • Deviation Management • Change Control Management • Root cause analysis (RCA) • Writing & updating SOPs & Work Instructions • Yellow belt / improvement projects / problem-solving thinking • Process Risk Inventory & Evaluation • HAZOP/LOPA studies • Identifying and testing Safety Critical Loops
• Process Safety Testing: This function mainly consists out of safety investigation on chemical production processes. With techniques such as reaction calorimetry (RC1 and Multimax), screening calorimetry (DSC and Seteram C80), adiabatic calorimetry (PhiTec), gas flow and pressure rise measurements (TSu), potential unsafe chemical production steps are investigated. • Making qualification / validation protocols for the used equipment. • Optimization of process safety studies. • Participate with HAZOP / LOPA studies
Troubleshooting HPLC, dissolution analyses, FMS pressure/water and oxygen analyses, UV/VIS spectrometry according to GLP
• Research on degradation of PLGA films used for innovative medication devices • Setting up a performance / qualification / validation protocol for Size Exclusion Chromatography (SEC) • Thesis in English
• Research on the influence of water on the bonding strength between copper and ABS • Gained experience in surface treatment of metals and polymers • Results of internship contributed in three articles