Basel, Basel, Switzerland
More than 15 years senior professional for LC/MS/MS method development Instruments: AB Sciex API 4000, Agilent 6550 Q-Tof, Thermo LTQ, Orbitrap, LCQ Deca, More than 20 years work experience in GC/MS (Quadrupol- and Ion trap- MS; EI and CI) Instruments: Agilent GC/MSD, Shimadzu QP-2010, Thermo GCQ Software: Agilent Chemstation and Masshunter (LC, LC/MS, GC/MS), AB Sciex Analyst (LC/MS/MS); Thermo Xcalibur (LC/MS, GC/MS) Extensive knowledge in organic trace analysis Profund knowledge in Migration and Extractables & Leachables investigations Method development and validation (ICH, bioanalytical method validation), sample preparation of different matrices (blood, plasma, serum, tissue, environmental samples) Profound knowledge in GLP/GMP regulated work Many years of GMP/GLP audit experience; by authorities (FDA, Swissmedic, BAFU) and customers (pharma companies from CH, EU and USA) Supervisor for a lab training at QCC in Abu Dhabi "ICH method validation with LC/MS"
Topic Expert Oligonucleotides - Mass Spectrometry
SELECTED PROJECTS 2007-2014 Extractables & Leachables Different extractables studies on container closure systems. Leachables analysis of rubber oligomers in Propofol drug product (method development, validation and analysis of stability samples) Migration Method development: migration of different methacrylates in the ppt level. HCB migration out of pigments in the ppt level. Bioanalysis Quantification of perfluorinated compounds in rat tissue and fat Determination of Triclosan (free and conjugated) in plasma and tissue homogenisate LC/MS/MS method development for the quantification of a phospholipid (new API) in human serum Quality control Determination of the impurity profile of a phospholipid (new API) ICH validation of a QC method for the determination of impurities in a phospholipid (new API) with LC/MS Cleaning validation for different cytostatica (method-development and validation, analysis of swabs and filter samples) Metabolite Identification Metabolite identification of perfluorinated compounds in rat tissue Identification of photodegradation products of a new bactericide
Senior scientist for trace analysis GMP project responsibility (method development, validation, instrument qualification, composing of quality relevant documents) GLP study director in multiple environmental studies; 2013 STA Award of the US Environmental Protection Agency Main responsibility for the LC/MS laboratory (method development; system qualification, maintenance)
Senior scientist for trace analysis GMP project responsibility (method development, validation, instrument qualification, composing of quality relevant documents) GLP study director in multiple environmental studies Main responsibility for the LC/MS laboratory (method development; system qualification, maintenance) Expert for the determination of perfluorinated compounds in biological samples