Brisbane, Queensland, Australia
Experimental Preclinical/In Vivo Pharmacologist/Toxicologist Founder & Principal Consultant, PharmEthos Consultancy With over 20 years in drug discovery, I specialize in in vivo pharmacokinetics, pharmacodynamics, and toxicology, focusing on optimizing oral drug delivery and efficacy in chronic pain and inflammatory disease models. My expertise spans the design and execution of complex in vivo experiments, drug extraction and quantification using LCMSMS, and adherence to animal ethics and regulatory standards. My work has been supported by leading pharmaceutical and biotech companies, including Pfizer, Glaxo, AstraZeneca, Atai, Aptar, and Preveceuticals. I am skilled in developing, optimizing, and validating methods for drug testing, and have extensive experience in GLP, NATA-accredited labs, GCP, and clinical trials. I sat on an AEC at the University of Quueensland for many years as a Cat B member and Co-Chair... a role that inspired me to found PharEthos Consultancy. I am committed to the 3Rs in preclinical research and the Australian Code of Practice. I currently volunteer as a Scientific member of the Gold Coast Human research ethics committee. I have tested over well over 100 compounds in vivo for efficacy, pharmacokinetics, oral bioavailability, brain delivery, and tissue distribution in various disease models. My consultancy, PharmEthos Consultancy, offers expert guidance on optimizing preclinical pharmacology, toxicology, and animal ethics solutions. I am a registrant of the Australasian College of Toxicology and Risk Assessment (RACTRA), and contribute to the scientific community as an Associate Editor at Frontiers in Neurological Drugs and a Review Editor at Frontiers in Pharmacology and Frontiers in Drug Discovery.
Stability (LCMS) and sterility (culture) testing of various clinical medicine formulations for use in human clinic
PharmEthos Consultancy (https://dryonk78.wixsite.com/pharmethos-consultan) Optimizing In Vivo Research for Maximum Impact PharmEthos Consultancy is dedicated to enhancing the outcomes of in vivo pharmacology, toxicology, and pharmacokinetic research. We assist researchers in designing, planning, and executing their projects to ensure adherence to the NHMRC Code of Practice and the global 3Rs of animal research. Our Services Include: In Vivo Experimental Design: Expertise in designing experiments for drug discovery, efficacy, and toxicology research. Preclinical and Pharmacokinetics: Guidance and services for in vivo pharmacokinetics, bioavailability, biodistribution, and bioequivalence studies. Drug Extraction: Techniques for extracting drugs from tissues and biological fluids. LCMS/MS Techniques: Design, development, optimization, and validation of LCMS/MS methods for quantifying drug content in pharmacokinetic, pharmacodynamic, and biodistribution studies. Animal Ethics Applications: Assistance with animal ethics applications through academic research institute animal ethics committees. For queries or to discuss how we can support your research, please contact us directly at [email protected].
• Design preclinical toxicology and toxicokinetic studies for sponsor-based (APAC, USA, Europe) compounds as part of a GLP and NATA accredited Contract Research Organisation. • Lead and guide a team of researchers through these research studies on behalf of the client • Frequent high level scientific communication with sponsors to discuss their study progression, results, recommendations and research out comes • Prepare high level scientific toxicology/toxicokinetic reports for the client.