Greater Oxford Area
I am an experienced Lead Scientist with a strong track record in R&D, analytical chemistry and synthetic organic chemistry. My experience has been gathered from the biotechnology industry, the chemical industry and academia, working as a member of multi-disciplinary teams and working independently. I have 16 years’ experience in glycoanalytical chemistry, involving the development and implementation of analytical techniques and methods for enzymatic and chemical glycan release of glycans and post release derivitization for UHPLC, LC-ESI-MS and MALDI-TOF analysis of biopharmaceutical glycoproteins and glycomics samples (blood, serum, plasma) for comparability studies and biomarker discovery. I lead the development and automation of sample preparation and analytical methods at Ludger for the higher throughput analysis of protein glycosylation. This has included the transfer of developed methods to client led glycoanalytical services and in-house client use. Through this I have developed and implemented a high thoughput method for the analysis of glycosylation biomarkers in plasma and serum. I have also developed and implemented a GX-mAb glycosylation service (HTP glycoanalysis of monoclonal antibody therapeutics) to enable a wide range of clients to use Ludger as their CRO for biopharmaceutical mAbs analysis at all stages of the product lifecycle. I lead the glycoanalytical work for collaborations within Ludger’s R&D group, and perform glycoanalytical work on various biopharmaceutical samples, including mAbs (IgG and IgE), FSH, EPO, HCG and Biosimilars, and glycomics samples, including plasma, serum and whole cells. I have worked within multiple grants funded by the EU (including High Glycan FP7, IBD-Biom, GlycoPar, GlyCoCan, GlySign, A4B, Nanocarb), training and supervising senior scientists, scientists and PhD students to enable them to perform multiple glycoanalytical techniques and automated methods, and working in teams to reach the defined objectives and project milestones.
• Leading the Production team to ensure successful delivery of all glycan analysis products to support sales • Leading finished good shipment to fulfil customer deliveries • Work with staff in Ludger to ensure minimum stock levels are maintained, provide training where required • Continual development of production staff • An integral part of a cross functional team to ensure the efficient running of the business • Maintaining and driving compliance improvements • Liaising with Business Development to provide input into product availability for sales order fulfilment, marketing strategies and supporting documents • Develop plans to ensure long term client support are initiated and maintained • Responsible for budget setting, business planning and meeting sales targets. • Communicating production activities to the wider organisation • Providing technical support for Ludger clients • Collaborating with all internal teams to ensure Ludger goals and targets are achieved • Supporting the Glycoprofiling team with ensuring products are available in a timely manner
Key responsibilities • Project leader: Development and automation of Ludger sample preparation and analytical methods, including modifying and optimising current methods, for automation and higher throughput analysis of protein glycosylation. • Integration of multiple glycoanalytical techniques, UHPLC, LC-MS and MALDI, to provide a platform for higher throughput, orthogonal analysis of glycoproteins. • Technically assessing and applying developed, automated methods for comparison of biopharmaceutical glycoproteins and glycomics samples for comparability studies and biomarker discovery. • Project leader: Ludger’s GX-mAb glycosylation service (HTP glycoanalysis of monoclonal antibody therapeutics) involving the development, implementation and running of the service: study proposals and plans, sample reception, sample preparation, sample analysis, data analysis, report writing, liaising with clients • Product champion: Product and method development within R&D to take new products from conception through to beta build and on to sales build and marketing using Ludger’s Development product pipeline. One of my responsibilities was as the Deputy for QC sign off of products. • Validation of Ludger glycoanalytical methods and technology, producing validation reports and documents in accordance with ISO9001:2008 framework and ICH Q2(R1) guidelines • Responsible for Glycoanalytical work for clients through glycoprofiling, Ludger’s CRO department, on various biopharmaceutical samples including mAbs, FSH, EPO and Biosimilars: sample reception, sample preparation, sample analysis, data analysis, report writing, liaising with clients.
Key responsibilities Process Research and Development: Development of alternative routes to synthesize final compounds, route scouting and small scale chemistry. Custom Prep: Synthesis of API to cGMP up to 20L scale in the laboratory. Key experience Working as a member of different teams, working to tight deadlines. GMP trained and experienced.
Key Research Synthesis of acinetoferrin homologues and petrobactin and homologues (bacterial iron chelators) as probes for iron transport in bacteria, synthesis of beta-amino peptides, synthesis of lipophilic-polyamine DNA vectors, synthesis of aryl-polyamine conjugates to probe the polyamine transport system. Position obtained by personal contact with Otto Phanstiel at the Gordon Conference on Polyamines in June 2001. Key experience Writing a number of peer-reviewed publications on different synthetic pathways. Undergraduate supervision