Basel, Basel, Switzerland
Strong expertise in analytical chemistry with focus on chromatography coupled mass spectrometry. 29 years of experience in chemical/pharmaceutical industry. Recognized expert for gas chromatography mass spectrometry. Research activities on synthesis of chiral stationary phases for gas chromatography and fundamental contribution on development of high temperature gas chromatography coupled to mass spectrometry. Pioneer for metabolite identification at early stage of drug development using non-radioactive labelled drug candidates. Establishment of dedicated analytical techniques for structure elucidation of metabolites and in vitro / ex vivo assays. Development of capillary HPLC / high resolution MS technology, electrochemistry / MS and micro-scaled preparative HPLC/MS in order to isolate metabolites for structure elucidation by NMR spectroscopy. Involvement in the introduction of specific in vivo animal models for metabolism studies, such as the bile duct-cannulated rat, and non-invasive bile collection from the dog. Key contribution for foundation of metabolism and pharmacokinetic department in a drug discovery setting. Management of metabolite identification group which supported chemistry projects in drug research. Strategic guidance of drug discovery projects in the optimisation process and mentor for junior scientists.
BA Representative
Heading a group of scientists, strong expertise on structural characterization of metabolites in early phase of drug development