Basel, Basel, Switzerland
Experienced Project Chemist with a demonstrated history of working in the chemicals industry. Skilled in Method Development, Liquid Chromatography-Mass Spectrometry (LC-MS), NMR Spectroscopy, and Synthetic Organic Chemistry. Strong research professional.
Support and deputise Head Peptide Production Manufacturing products according to defines regulations (ISO / GMP environment) and quality standards on lab to kilo lab scale (synthesis and analytics) Improve and optimize existing production processes -change rout, solvents, reagents, work-up conditions or purification method -purification process transfer from LH-20 Sephadex to RP-C18 of all our peptides -Ion exchange process transfer from external location to main site Oversee and execute product development projects -new rout, different condition or new formulation, new products Organize all aspects of production lab -qualified and maintained equipment Responsible for safe operations in the lab Responsible to issue the production planning in line with the demand -Up to 70 final products with up to 11 steps each (SPPS and LPPS) -availability of all material (order of chemicals in the correct amount and quality, make sure they are delivered, analysed and released on time for production), capacity (personnel, equipment and workspace) Coordinates with third parties the outsources activities -make sure that the suppliers lead-time for starting material are in accordance with our demand plan timeline Guide and support lab technicians Guide and support interns Advice, write, troubleshoot and or support in all aspects of a scientific or manufacturing matter, product expert peptide: REW (rework / reprocess) Deviation (planned and unplanned deviations) CAPA (corrective and preventive actions) OOS/OOE (out of specification / expectation) REC (customer complaint) RET (retest) MOC (management of change) SOP (standard operating procedure) BR (batch record) BRR (batch record review) Documentation for new equipment: URS (user requirements), LH/PH (requirements specification / implementation specification) Qualification plan IQ/OQ documentation Qualification report Part of the planning and designing team of the new peptide production facilities.
Custom sythesis Hands-on research, development and improvement of known and new synthetic routes to meet specifications Working with complex molecules including Active Pharmaceutical Ingredients (APIs) Developing scalable process using in-house and state-of-the-art technology, including statistical design of experiments (DOE) and cost estimates (FTE, sourcing) Support of process scale-up in Kilo-Lab Managing projects train and support interns and graduates (BSc candidates)
Support the set-up of a metabolism database in MAP. Check and correct the chemical structures of metabolites of legacy data.
Teaching classes, pre- and post-processing of lessons, provide exercise and exams.