Wirral, England, United Kingdom
Responsible for the day-to-day management and administration of the Liverpool Experimental Cancer Medicine Centre. Duties included, but were not limited to trial activity reporting, facilitating the progression of translational research projects to meet objectives, management of (non-CTIMP) clinical studies, acting as a Centre representative at internal and external meetings, budget oversight and taking an active role in patient and public engagement activities.
Dr Shankar Varadarajan lab (11/2017 - 06/2023): Targeting mediators of apoptosis and/or cell metabolism in squamous cell carcinoma of the head and neck. I have been involved in a range of projects, including, but not limited to: - Exploring the therapeutic potential of BH3 mimetics in head and neck cancer. - DHODH as a potential therapeutic target in head and neck cancer. - mTOR targeting in head and neck cancer. - The role of CIP2A in head and neck cancer. - The role of ER shaping proteins in mitochondrial dynamics, bioenergetics and apoptosis. _________________________ Dr Jason Parsons lab (11/2014 - 11/2017): Investigating the cellular response to complex DNA damage induced by ionising radiation, with a focus on head and neck cancer. I performed a deubiquitylase siRNA library screen, in conjunction with irradiation using x-rays (University of Liverpool), alpha particles (University of Oxford) and high- and low-energy protons (Clatterbridge Cancer Centre), to identify enzymes involved in the processing of complex (clustered) DNA damage and therefore potential therapeutic targets. In parallel, I examined the impact of specific histone modifications on complex DNA damage repair, and assessed the influence of the human papillomavirus on head and neck squamous cell carcinoma radiosensitivity.
Dr Diana Moss lab: I was invited to continue working on the project established during my PhD (see "Education" section), to further investigate the ability of the chick embryonic environment to reprogram neuroblastoma cells.