Prisha Yadav

Bioinformatics Researcher | Spatial Transcriptomics · NGS Pipelines · scRNA-seq | Nextflow · R · HPC | UCL

United Kingdom

About

I build bioinformatics pipelines that turn large, complex genomic datasets into reproducible, clinically meaningful results. Currently working as a Bioinformatics Intern at UCL Genomics, I automate and optimise Nextflow pipelines for Visium HD spatial transcriptomics on HPC clusters, and conduct downstream analysis in R using Seurat - covering clustering, spatially variable features, deconvolution, and multi-modal integration. Alongside this, my MSc thesis at the UCL Great Ormond Street Institute of Child Health involves processing VCF data from 1,000+ patients across two longitudinal cohorts to characterise viral evolution and drug-resistance dynamics. I have a first-author publication in Elsevier's Life Sciences journal on ferroptosis mechanisms in doxorubicin-induced cardiotoxicity - work that sits at the intersection of structural bioinformatics, multi-source data integration, and translational research. My technical toolkit spans R, Bash, Nextflow, Seurat, DESeq2, edgeR, and HPC-based workflow development. I bring a strong focus on reproducibility, documentation, and clear communication of findings to both computational and wet-lab audiences. I am actively seeking bioinformatics roles - particularly in spatial/single-cell genomics, NGS pipeline development, or multi-omics research - where I can contribute rigorous computational work to projects with real clinical or translational impact.

Experience

  • MSc Bioinformatics Thesis Researcher at UCL Great Ormond Street Institute of Child Health
    Apr 2026 - Present · 4 mos

    My MSc dissertation at the UCL Great Ormond Street Institute of Child Health focuses on computational virology and genomic epidemiology. I process VCF datasets from over 1,000 patients across two longitudinal cohorts using custom R pipelines, with a strong emphasis on data integrity, automation, and traceability. The work involves engineering QC checkpoints and variant-calling workflows to characterise drug-viral dynamics, as well as multi-cohort comparative statistical analysis and phylogenetic reconstruction to dissect viral evolution and transmission patterns - directly supporting therapeutic development research.

  • Academic Representative at Students'​ Union UCL
    Oct 2025 - Present · 10 mos

  • Sustainability Ambassador at UCL
    Oct 2025 - Present · 10 mos

  • Kalpana Mentee at VigyanShaala International
    Oct 2023 - Nov 2024 · 1 yr 2 mos

  • Medical Laboratory Intern at Apollo Hospitals
    May 2024 - May 2024 · 1 mo