Ingelheim am Rhein, Rhineland-Palatinate, Germany
New Mechanisms Parasitology Establishing a drug profiling platform on antiparasitic targets: Assay development & validation, scientific and budgetary supervision of external partners. Management of internal and external research projects in a global matrix organization. Scientific evaluation of potential new targets for parasiticides.
Whole organism parasite screening. Development and implementation of assays for medium and high throughput phenotypic screening of ecto and endoparasites. Setting up of automation methods for parasite screening : workflow conceptualization and programming. Development of immunohistochemistry methods for protein localization in parasitic nematodes.
Ubiquitin-like modifiers as new biomarkers and targets in Acute Myeloid Leukemia: Identification of a ubiquitin-like modification signature to predict AML response to chemotherapeutic drugs. Development of a substrate-based assay to measure conjugation activity of ubiquitin like modifiers. Development and activity assessment of peptidic SUMOylation inhibitors
In silico affinity prediction of monoclonal antibodies: Development of a computational method to predict affinity between an antibody and its target
Computer modeling of interactions between acetylcholine receptors and nicotine derivatives Prediction and development of new ligands Organic synthesis