Pauline Lempens

Molecular biologist One Health surveillance

Eindhoven, North Brabant, Netherlands

About

I am a biomedical scientist passionate about infectious diseases. I have ample experience with microbiological and molecular laboratory techniques, next generation sequencing, data management, bioinformatics, and statistics. During my doctoral research at the Institute of Tropical Medicine in Antwerp, I investigated resistance to first-line antibiotics in Mycobacterium tuberculosis. Using whole genome sequencing, targeted deep sequencing, phenotypic drug susceptibility testing, and clinical data, I investigated which bacterial genomic mutations predict differences in resistance levels and whether those mutations are associated with treatment failure. In addition, I analysed the transmission fitness of drug resistance-causing mutations in a cohort of patients in Bangladesh. In my role as tuberculosis consultant at KNCV Tuberculosis Foundation in the Netherlands, I assisted in the implementation of innovative tuberculosis diagnostics and the execution of accompanying implementation research. In addition, I contributed to guideline development, patient advocacy, and education of public health professionals.

Experience

  • Molecular biologist One Health surveillance at Rijksinstituut voor Volksgezondheid en Milieu
    Sep 2024 - Present · 1 yr 11 mos

  • Tuberculosis Consultant at KNCV Tuberculosis Foundation
    Aug 2020 - Aug 2024 · 4 yrs 1 mo

  • Institute of Tropical Medicine in Antwerp (ITM) (6 yrs 8 mos)
    • PhD student
      Sep 2016 - Apr 2023 · 6 yrs 8 mos

    • Course Coordinator and Teacher
      Feb 2017 - May 2019 · 2 yrs 4 mos

      Coordinating and teaching in ITM’s course “Clinical Decision-Making for Drug-Resistant Tuberculosis”, an interactive training on clinical aspects of DR-TB diagnosis and care (https://edu.itg.be/courses/clinical-decision-making-for-drug-resistant-tuberculosis).

  • Department of Immunology, Allergology and Rheumatology at University of Antwerp
    Sep 2014 - Jan 2015 · 5 mos

    Master internship