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Vittorio Sebastiano Lab at Stem Cell Biology and Regenerative Medicine. My work is centered around preimplantation embryo development and stem cells. My approach is studying catabolic processes/metabolism/chromatin dynamics in preimplantation embryos/stem cells that can affect cellular developmental quality.
I have co-founded the SmartLens Biotech startup that aims at helping glaucoma patients. Currently, the company is based in Santa Clara, CA
BIO160. Taught by Dr Kristy Red-Horse, Department of Biology. This course covers the molecular mechanisms underlying the generation of diverse cell types and tissues during embryonic and post-embryonic animal development. Topics include the role of cell-cell communication in controlling developmental decisions, the organization and patterning of large groups of cells via morphogen signaling, the specification of individual cell types, and the role of stem cells in development. The course emphasizes the experimental logic and methods of research in developmental biology and includes discussions of research papers.
BIO44x (BIO45) Investigate yeast strains that are engineered to express the human protein, p53, and use modern molecular methods to identify the functional consequences of p53 mutations isolated from tumor cells. Learn about the protein's role as a tumor suppressor through lectures and by reading and discussing journal articles. Use molecular visualization programs to examine the structure of wild type and mutant p53 proteins. Formulate a testable hypothesis and assay the ability of mutant p53 to direct expression of several reporter genes. During guided reflection, formulate further analyses to determine whether mutant p53 is present in the cell, can bind to DNA, and/or can enter the nucleus. Conduct lab experiments, present findings through a team oral presentation, as well as a scientific poster.
My research focus is on stem cell biology, fertility and embryo development. I collaborate with Engineering Department to use novel techniques and devices for stem cell research, and apply it to enhance fertility and embryo development. Specific lab expertise: -mouse work -mouse reproduction -preimplantation embryo culture -in vitro fertilization -DenseMag platform (collaboration with Demirci lab) -confocal fluorescent imaging -mouse embryonic stem cell derivation from blastocysts -human embryonic stem cell culture -human iPSCs -FACS sorting and analysis -ATAC-seq -RNA-seq -Data analysis, Image analysis tool Velocity, R, Matlab, Python