Ireland
Experienced process chemist with proven ability in the pharmaceutical industry. Expertise in process optimisation, scale-up and technical transfer aspects of API chemistry, including synthesis and recrystallisation of a diverse range of organic chemicals (macrolides; fluoroquinolone antibiotic; nucleoside; amino acids; phosphorus containing biomolecules; heterocycles and carbohydrates) as well as organometallic chemistry & carbon-carbon bond formation. Ability to work on own initiative or as part of a team. First-class analytical and problem solving skills with a talent for identifying and solving complex problems whilst achieving high-quality results. Able to communicate ideas clearly, concisely and persuasively. Willing to learn new tasks and develop new skills.
• Synthesis and recrystallisation of a diverse range of organic chemicals, working on a range of projects • Participated in technology transfer of a variety of products to the Arklow site • Expertise in nucleoside chemistry, in particular synthesis of human purine nucleoside phosphorylase inhibitor • Expertise in resolution of racemic pyrazinoisoquinoline mixture and acylation to synthesise praziquantel • Synthesis of cinnoline derivative for indications in hepatology and gastroenterology • Synthesis and crystallisation of organobismuth compound used to treat eye infections • Expertise in synthesis of tricyclic anti-depressants and their derivatives • Expertise in synthesis of tricyclic anti-histamines and their derivatives • Expertise in the synthesis of phosphorus containing biomolecules • Provided support for QC, preparing reference standards internally and for regulatory agencies, e.g., EDQM • Played vital role in two process improvements realising annual savings of €350,000 • Provided support to manufacturing for Grignard reaction • Synthesis and recrystallisation of high-quality biocides • Performed use tests • Supported solvent studies and generation of solubility data for reactor cleaning • Wrote weekly reports and delivered presentations for customer • Wrote a variety of reports (work-in-progress, research reports, equivalency reports) • Wrote batch records • Familiar with DMAIC methodology (OPEX certified Sep 2019) • Prepared nitrosamine risk assessments for products manufactured at Arklow
Provided lab technical support to execute and troubleshoot lab processes. • Synthesis of macrolide possessing anthelmintic properties and fluoroquinolone antibiotics. • Responsible for writing monthly progress reports for the Head of Chemical Synthesis. • Presented seminars as part of role.
Merck are one of the largest pharmaceutical companies in the world, • Quantification of active pharmaceutical extracted from samples of Cyclobenzaprine HCl tablets, using a Dionex solvent extractor. • Use of High Performance Liquid Chromatography (HPLC) • Preparation of specially prepared solutions of known concentration and dilution (of Cyclobenzaprine HCl tablets) in order to make a valid comparison of the amount of active extracted.