Dundalk, County Louth, Ireland
I have experience in downstream process development of microbial and mammalian proteins. Experience with GE Healthcare AKTA line of chromatographic systems and Tangential flow filtration systems. Overseeing all aspects of downstream process development and bioprocess unit operations, including centrifugation, depth filtration, chromatography, TFF, viral inactivation and viral filtration Design of Experiments - Quality by Design approach Protein Biochemistry ( Glycosylation, Charge variants, Aggregates, Degradation, Protein folding, etc.) General analytical methods applicable for proteins (HPLC, Electrophoresis and Assay development) Downstream technology transfer to cGMP facility Responsible for meeting project goals within time and budget constraints Specialities: Downstream process development, Analytical development, Protein Biochemistry and Pre-clinical trials.
Process development
Downstream process development for microbial and mammalian recombinant proteins Development of platform technology for purification of Monoclonal antibodies and Fusion proteins Process scale up Project Management Review of high quality technical development and technology transfer reports
Purification of recombinant protein of Japanese Encephalitis virus for the investigation of its pathogenic mechanisms.