Nathalie Ritter

About

Organisation and realisation of discovery and development preclinical studies, data analysis, reports redaction and communication, results upload in databases

Experience

• Research Associate in Rare Blood Disorders at Roche
  Apr 2024 - Mar 2025 · 1 yr

  Study the effect of compounds on Hemophilia in vitro, ex vivo and in vivo

• Laboratory Technician in the Hall Laboratory at Biozentrum, University of Basel
  Jul 2022 - Mar 2024 · 1 yr 9 mos

  Study of metabolic alterations in liver cancer:  Performing in vivo experiments in mice models of Liver Cancer: L-dKO, Ctrl and mice PDX with Liver Cancer organoids  Fixation and Paraffinization of mice livers and other organs, paraffin block preparation, sectioning with microtome,  Slides preparation, Haematoxylin-Eosin staining or IHC, Microscopy  Cell culture in HCC cells: SNU-449, Huh7, HEK293T cells  qPCR, Western Blot, Clonogenic growth assay, Immuno-purification. Managing and maintaining transgenic mouse lines:  Genotyping, breeding set-up, euthanasia of surplus mice  PCR protocols set-up for genotyping of new mice lines, export of mice lines Other responsibilities:  Organization of the laboratory, ordering, special waste management  Responsible for the paraffinization device and the Microtome

• Scientific Associate in DMPK at Idorsia Pharmaceuticals Ltd
  Jun 2017 - Mar 2022 · 4 yrs 10 mos

  Preclinical Development Pharmacokinetics and Metabolism Laboratory: Organisation and realisation of discovery and development studies in rats and mice, PK data analysis, report redaction, communicate scientific results to DMPK project leaders, upload data into databases. Provide training and support to colleagues. May to December 2019, During pregnancy, assignments outside of the lab: For Preformulation and Preclinical Galenics department, Physchem Lab support:  Standard Solubility and Log D -> protocols, data analysis, results upload into database, communication of the results to the chemists.  Creation of Standard Solubility Screening Manual. For DMPK, PK Lab support:  PK statistical analysis, reporting, communication of the results to the project Rep and upload of the results into database, Narcotic usage database  Standard Protocols creation or updates, Phoenix template creation and updates

• Research Associate in DMPK at Actelion (now Janssen Pulmonary Hypertension)
  Nov 2008 - Jun 2017 · 8 yrs 8 mos

  Preclinical Development Pharmacokinetics and Metabolism Laboratory: Practice pharmacokinetic and mechanistic studies in rats and mice.

• Animal and cellular biology Technician at XenTech
  Jul 2008 - Sep 2008 · 3 mos

  Tested toxicity and efficacy of antitumour compounds in athymic nude mice bearing human’s tumour