Basel, Basel, Switzerland
I am a passionate and dedicated researcher with 10+ years of experience in pharmaceutical industry in antibiotic research and development. I have a demonstrated history in drug discovery of small molecules and an advanced understanding of translational aspects from preclinical research to clinical development and an extended track record in grant attraction. I have a PhD in biochemistry from the ETH Zurich, was a Postdoc at the University of Lausanne.
Oversight and implementation of antibiotic clinical development program (preclinical to Ph. 2) o Leadership of the cross functional study team from industry and academia consisting of in vitro microbiology, in vivo pharmacology, toxicology, CMC, regulatory and clinical science and operations o Management of inhouse and outsourcing activities including risk mitigation, budget, timelines and reporting o Management of vendors, monitoring of the analyses, review of study data and reporting according to GCPs and GCLPs o Contribution to the clinical development strategy o Writing of clinical study protocols, IB, and IMPD o Preparation and review of regulatory documents such as QIDP, ODD and for regulatory agencies o Design and management of non-clinical pharmacology plans (in vitro, in vivo, hollow fiber, toxicology) to support clinical stage program o Coordination and support of internal and external interfaces within clinical studies and build up strong relationships with key opinion leaders Project Coordinator and Communication Champion of the IMI-funded TRIC-TB project
Coordination of national and international research projects in small molecule drug discovery in anti-infective R&D. Directing the BioVersys screening and biochemistry research to support HIT to LEAD development. Establishing networks of external collaborations and outsourcing strategies to optimize HIT to LEAD to pre-clinical candidate development. One of the discovery projects was awarded with a CARB-X grant.
Organization and execution of courses for bachelor students in biology and medicine
How is membrane homestasis regulated? Implications of SNARE and accessory proteins in membrane fusion and fission using yeast vacuoles as model system
Structure/function analysis of VEGF and VEGFR signalling
Involvement of molecular chaperones and folding enzymes in folding, quality control and ER-associated protein degradation