Heidelberg, Baden-Württemberg, Germany
As a senior scientist at Gen-H I am focused on strain optimization and strain development, mainly through the modification of the E. coli genome. Latest publications: Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides; Nilanjan Ghosh Dastidar, Nicola S. Freyer, Valentyn Petrychenko, Ana C. de A. P. Schwarzer, Bee-Zen Peng, Ekaterina Samatova, Christina Kothe, Marlen Schmidt, Frank Peske, Antonio Z. Politi, Henning Urlaub, Niels Fischer, Marina V. Rodnina & Ingo Wohlgemuth; Nature Communications 2025; 16:9568; https://doi.org/10.1038/s41467-025-65298-7 Method for plasmid-based antibiotic-free fermentation; Katherine E. Brechun, Marion Förschle, Marlen Schmidt and Harald Kranz; Microbial Cell Factories 2024; 23:18 Application of an Escherichia coli triple reporter strain for at-line monitoring of single-cell physiology during L-phenylalanine production; Manh Dat Hoang, Dieu Thi Doan, Marlen Schmidt, Harald Kranz, Andreas Kremling and Anna-Lena Heins; Eng Life Sci. 2022; https://doi.org/10.1002/elsc.202100162 Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity; Alexandra Vaisman, Krystian Łazowski, Martin A. M. Reijns, Erin Walsh, John P. McDonald, Kristiniana C. Moreno, Dominic R. Quiros, Marlen Schmidt, Harald Kranz,Wei Yang, Karolina Makiela-Dzbenska and Roger Woodgate; Molecular Microbiology 2021; 116: 909 CroSR391, an ortholog of the λ Cro repressor, plays a major role in suppressing polVR391-dependent mutagenesis; John P. McDonald, Dominic R. Quiros, Alexandra Vaisman, Antonio R. Mendez, Jan Reyelt, Marlen Schmidt, Martín Gonzalez and Roger Woodgate; Molecular Microbiology 2021, 116: 877 Development and characterization of Escherichia coli triple reporter strains for investigation of population heterogeneity in bioprocesses; Anna-Lena Heins, Jan Reyelt, Marlen Schmidt, Harald Kranz and Dirk Weuster-Botz; Microbial Cell fact 2020, 19: 14