Munich, Bavaria, Germany
Main Research Focus: I) Developing of patient surrogate mouse models of solid tumours by using CRISPR technology II) Lung homeostasis and tumorigeneity - Role of deubiquitinating enzymes in controlling oncoprotein stability - Development of novel lung tumour models in mouse - Improvement of treatment regimes for lung cancer patients - Tumour heterogeneity in mouse lung cancer mimicking the human phenotypes - Translational research: from mouse model to human treatment - ex vivo organoid cultures for intestinal tumor cells and lung tumor cells - Utilisation of organoid cultures for drug screens III) Involvement of ubiquitinating and deubiquitinating enzymes in intestinal homeostasis and tumorigeneity - Role of deubiquitinating enzymes in controlling oncoprotein stability - intestinal stem cell dependency on crosstalk between E3 ligases and deubiqitinases - novel strategies to inhibit intestinal tumour formation - modulate essential proto-oncogenes in established intestinal tumours - Utilisation of organoid cultures - Establishing a human colorectal organoid bank Current external funding: Deutsche Krebshilfe DFG-GRK2243 German-Israeli Foundation grant