Manu Chakravarthy MD, PhD

SVP and Global Head of Cardiovascular, Renal and Metabolism Product Development @ Roche-Genentech

Greater Boston

About

With over 20 years of experience as a physician-scientist, I am passionate about advancing the understanding and treatment of human diseases with unmet medical needs. I currently lead the research and development function at Carmot Therapeutics, Inc., a biotechnology company that leverages a novel drug discovery platform to create innovative therapies for metabolic conditions such as diabetes, obesity, and liver diseases. I have a proven track record of delivering results across the drug development continuum, from discovery to registration, with expertise in cellular signaling, translational medicine, clinical pharmacology, biomarker development, clinical development, and regulatory affairs. I have successfully managed multiple global clinical trials, led cross-functional teams, and established strategic partnerships with external stakeholders. I also have a strong academic background, with an MD and a PhD in cell biology and physiology, and a clinical assistant professorship at Rutgers New Jersey Medical School. I enjoy teaching and mentoring the next generation of scientists and clinicians, and I am always eager to learn from others and share my insights. My mission is to bring my creativity, vision, and collaboration skills to make a positive impact on patients' lives and health outcomes.

Experience

  • SVP and Global Head of Cardiovascular, Renal and Metabolism Product Development, Roche-Genentech at Roche
    May 2024 - Present · 2 yrs 2 mos

  • Clinical Asst. Professor of Medicine at Rutgers New Jersey Medical School
    Jul 2009 - Present · 17 yrs

    Teaching Medical Students, Residents, and Endocrine Fellows; attend on the out-patient Lipid Clinic

  • Executive Vice President, Head of R&D and Chief Medical Officer at Carmot Therapeutics, Inc.
    Mar 2021 - May 2024 · 3 yrs 3 mos

  • Axcella (Cambridge, Massachusetts, United States)
    • Executive Vice President Clinical Development and Chief Medical Officer
      Aug 2020 - Mar 2021 · 8 mos

      Direct oversight of all phases of clinical development across several indications, regulatory affairs, quality, and scientific communications, and responsible for the strategic direction and oversight for Axcella’s clinical research and development activities.

    • Senior Vice President Clinical Development and Chief Medical Officer
      Aug 2017 - Aug 2020 · 3 yrs 1 mo

      Direct oversight of all phases of clinical development across several indications, regulatory affairs, quality, and scientific communications, and responsible for the strategic direction and oversight for Axcella’s clinical research and development activities.

  • VP, Global Head, Innovation Strategy and External R&D, Endocrine and Cardiovascular at Eli Lilly and Company
    Aug 2015 - Jun 2017 · 1 yr 11 mos

    Responsible for external search and evaluate activities and R&D strategy in support of diabetes (+ complications) and cardio-renal efforts to shape and implement external innovation for Lilly.