Leiden, South Holland, Netherlands
Associate Director R&D with a keen interest for translational research in a preclinical setting. Background in design of gene- and antisense therapies. Experienced in leading a research project and managing a small team of scientists and technicians.
• Leading and coordinating activities of a small research team • Identifying and assessing new therapeutic targets • Project lead of CNS program; coordinating overall research activities • Collaborate with global program team to advance gene therapy program
• Management of small research team • Research lead on preclinical CNS project • Coordinate initial design and proof of concept for gene therapy constructs
• Preclinical research lead for SCA3 program • AAV cargo design and screening of miRNAs and expression constructs • Coordination of in vivo studies at CROs
Postdoc in the Willeke van Roon-mom lab - Performed translational research for SCA3 and Huntington disease - Designing and testing antisense oligonucleotide therapies in cells and animal models - Writing of scientific publications - Presenting at international conferences - Collaborate research with pharmaceutical companies
PhD student in the Willeke van Roon-Mom lab Doctoral thesis "Developing and antisense oligonucleotide treatment for Spinocerebellar Ataxia Type 3" https://www.offpage.nl/ebooks/ibuw3air4wokgqlymb6y/ - Designed antisense oligonucleotides (AONs) for ataxin-3 exon skipping - Tested and optimized AONs in cell culture (RNA and protein analyses) - Screened AON efficacy in SCA3 mice (molecular and behavioral readouts) - Performed wide range of lab based analyses (qPCR, Western blotting, molecular cloning, protein production, protein interaction, histology, RNA sequencing, etc) - Published scientific papers and presented results at various conferences