Zurich, Switzerland
o CMC representative in internal core project teams o Responsible for external drug substance and drug product development for NCE o Responsible for external non-GMP and GMP manufacturing of drug substance and drug product to support tox and clinical studies o Contributing to and drafting of scientific reports, articles, patents, and regulatory documents (IND) o Vendor oversight and management
As part of a multidisciplinary project team: o Technology transfers from customers to Lonza o GMP production of early and late-stage APIs o Process optimization (QbD, DOE), qualification (P-FMEA), and validation o R&D support during production including deviations, investigations, and problem solving Weekly or biweekly customer updates including presentations and/or reports Laboratory head and project-based supervision of lab technicians Trained 200+ Lonza Visp employees about "Be a Safety Leader" (work safety)
“Synthesis of GDB-Derived Tricyclic Scaffolds for Medicinal Chemistry” in the group of Prof. Jean-Louis Reymond • Designed and synthesized in close collaboration with computational chemists novel 3D building blocks to increase selectivity, activity, and water solubility of drugs. • Enantioselective synthesis of “triquinazine” as a new 3D scaffold • Using triquinazine to create a selective, sub-nanomolar JAK inhibitor • Supervision of Master and Bachelor theses
- Project management - Contributed to several products currently on the market - Supervision of an intern - Guiding internal trainings and carrying out internal audits - Responsible for in-process and final product quality control - Scale up, production process development and optimization
- Product development - Product quality optimisation - In-process and final product quality control - Creation of lab. operating instructions
100% Workload
Chemistry for Civil Engineering
The Synthesis of New PKB Inhibitors for Investigation of Sulfur-Arene Interactions. Under the Supervision of Birgit Lauber in the Research Group of Prof. F. Diederich, Laboratories of Organic Chemistry, ETH Zürich