Karsten Krug

Senior Director, Head of Bioinformatics at Frontier Medicines

Boston, Massachusetts, United States

About

Accomplished, results-oriented Computational Scientist with significant expertise in identification of computational needs and subsequent planning and implementation of workflows and pipelines. Experienced, team-oriented manager and mentor. 15 years of experience in analyzing large-scale genomic and proteomic data with a special focus on integrative analysis of data derived from multiple omics platforms. Former integral member of the NCI Clinical Proteomic Tumor Analysis Consortium (CPTAC).

Experience

  • Frontier Medicines (4 yrs 8 mos)
    • Senior Director, Head of Bioinformatics
      Mar 2026 - Present · 4 mos

    • Director - Head of Bioinformatics
      Mar 2025 - Feb 2026 · 1 yr

      Established bioinformatic support to advance clinical and pre-clinical programs and strengthen Frontier's platform capabilities.

    • Associate Director, Head of Bioinformatics
      Dec 2022 - Feb 2025 · 2 yrs 3 mos

      Leading the development and coordination of bioinformatic strategies across platforms and programs. Building, managing, and mentoring a high-performing team of computational scientists.

  • Broad Institute of MIT and Harvard (6 yrs 2 mos)
    • Senior Computational Scientist
      Jul 2020 - Nov 2021 · 1 yr 5 mos

      Integral member of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) of the NCI. Coordination of analysis efforts across multiple research institutions within the CPTAC network.

    • Computational Scientist
      Jan 2017 - Jun 2020 · 3 yrs 6 mos

      Development and application of computational approaches and pipelines for the analysis of multi-omics data sets, predominantly derived from cancer cohorts analyzed in the NCI Clinical Proteomic Tumor Analysis Consortium (CPTAC).

    • Post-doctoral Associate
      Oct 2015 - Dec 2016 · 1 yr 3 mos

      Development of proteogenomic data analysis pipelines to study phosphosignaling-affecting mutations in clinical cancer cohorts.

  • Proteome Center Tuebingen (Tuebingen)
    • Staff Scientist / Postdoc
      Aug 2013 - Sep 2015 · 2 yrs 2 mos

      Assembly and assessment of individualized protein databases derived from RNA-seq data. Comparative proteogenomics of human cancer cell lines. Bioinformatics support for research and core facility projects; support in maintenance of a heterogeneous IT environment.

    • Staff Scientist Bioinformatics
      Aug 2008 - Sep 2015 · 7 yrs 2 mos

      Bioinformatics support for research and core facility projects; support in maintenance of a heterogeneous IT environment.

    • PhD student
      Jan 2009 - Jul 2013 · 4 yrs 7 mos

      Ph.D. thesis: High accuracy mass spectrometry in refinement of genome annotation.

  • Research Assistant at Leipzig University
    Jan 2008 - Jul 2008 · 7 mos