Somerville, Massachusetts, United States
Scientist II in cancer biology with experience across biotech and academia, focused on advancing oncology therapeutics from discovery to development. Skilled in cell and molecular biology, in vivo pharmacology, and high-throughput screening, with proven contributions to regulatory IND documentation and cross-functional collaboration. Committed to translating scientific insight into impactful therapies for patients.
• Non-clinical lead for GB-4362 MMAE neutralizer from target nomination to IND • Led maintenance of experimental records, data traceability, and method documentation aligned with regulatory submission requirements. • Led preparation and cross-functional coordination of nonclinical data packages for regulatory filings and timeline delivery.
• Led assay dev, design and execute automated high throughput screening for GB-4362 MMAE neutralizer • Enabled robust centralized data analysis pipeline and model improvement for GB-4362 MMAE neutralizer by coordinating cross functional collaboration with informatics and computational biology ML teams
• Investigate mitochondrial DNA replication in prostate cancer and role of metabolism in the context of tumor heterogeneity as well as the interplay between tumor and tumor microenvironment
Laboratory of Angelo M. De Marzo MD, Ph.D. Thesis: Role of mtDNA copy number variations in Normal Tissues, in Aging, and in Prostate Tumorigenesis ● Designed, developed, and validated a quantitative in situ hybridization assay to visualize and quantify mitochondrial DNA (mtDNA) copy number in specific cell populations on tissues, leading to a first authored publication and a cover figure ● Applied the above in situ assay in normal and aging mammalian tissues and clinical cancer samples, and determined higher mtDNA copy number in stem/proliferative cell compartments in normal tissues as well as increased but greatly variable mtDNA copy number in prostate cancer ● Investigated the molecular mechanism(s) for the change of mtDNA copy number during prostate tumorigenesis in human and mouse prostate cancer cell lines and prostate cancer mouse models using genetic manipulation, pharmacological perturbations, immunoprecipitation, qPCR/ddPCR and imaging ● Forged collaboration with a bioinformatic team and performed data analysis on mtDNA copy number from whole genome sequencing data from laser micro-dissected prostate tissues and microarray data from human prostate cell lines ● Supervised and led junior scientists in the laboratory (technicians, graduate, and undergraduate students)
● Assist students during their experiment procedure ● Promoted safety in the laboratory and maintained the laboratory condition
● Designed and implemented an independent research project to investigate the roles of three putative Na-dependent cation chloride co-transporters in larval Aedes aegypti mosquitoes using molecular biology techniques including RNAi, Western Blot, quantitative PCR, and cation chromatography, leading to two abstract publications at national and international conferences
Laboratory of José J. Otero, MD, Ph.D. ● Conducted a research project to investigate the role of Cyclin A2 in DNA damage response in human glioblastoma cell lines using lentivirus based siRNA and Western Blot