Utrecht, Utrecht, Netherlands
Translational Research Oncology leader with 20+ years of experience in biological sciences across pharmaceutical industry/ biotech. Strong experience in oncology drug development from lead candidate selection to clinical phase studies. Experience with regulatory submissions including IND and NDA/BLA applications. Leads teams developing, validating, and implementing clinical biomarkers including pharmacodynamic and predictive biomarkers. Design of rational drug combination strategies. Skilled leader for experimental translational medicine organizations, including wet lab teams, computational biologists, and scientific teams to investigate basic and clinical biology. Skilled in working in matrixed, and multi-dimensional groups to deliver real world results with high impact on patient health. Currently leading the Translational Research and Bioinformatics teams at Merus, focusing on utilizing biomarkers and translational research to drive clinical development of the portfolio. Responsibilities: • translational Research Expert in international, multidisciplinary Drug Development teams • pre-clinical, clinical biomarker and translational research • computational research and bioinformatics • expert in management of Companion Diagnostic development • management of multiple international collaborations with academic research groups and CRO • mechanism-of-action / mechanism-of-resistance research in pre-clinical and clinical development • management of scientists and technicians • scientific publication, patents, presentations, regulatory documentation (IND/BLA/CTA filings) Specialties: antibody therapeutics, biomarkers, antibody drug conjugates, oncology, immunology, pharmacology, immunohistochemistry, bispecific antibodies, tumor immunology, translational medicine, companion diagnostics (CDx), computational sciences, bioinformatics, data management
Intern at Leadd B.V.