JC Hus

About

Experience

• Diagonal Therapeutics (Full-time · 4 yrs 4 mos)
  • Research Fellow
    Feb 2026 - Present · 5 mos

  • Senior Director, Informatics
    Jun 2023 - Feb 2026 · 2 yrs 9 mos

  • Director, Informatics
    Mar 2022 - Jun 2023 · 1 yr 4 mos

• Sr Scientist at Biogen
  Sep 2007 - Mar 2022 · 14 yrs 7 mos

  Experimental and computational modeling of small molecules, proteins, RNAs and their complexes: ‣ Simulation and structural biology support of small-molecule RNA splice-modulator R&D programs. Modeling of RNA/U1-snRNP based on cryoEM/X-ray/NMR data and MD simulations. ‣ Structure prediction using AI and ML algorithms. Deployed AlphaFold2 (through ColabFold) to predict 3D structures of U1 snRNP proteins and AAV surface proteins to support Gene Therapy efforts. ‣ Identification of small molecule modulators via fluorine fragment screening by NMR (won a poster award at the 2017 RNA NYAS conference). ‣ Lead the group accountable for NMR support of Medicinal Chemistry, Process Chemistry, and DMPK groups and 20 R&D projects/year. ‣ Partnered with Biologics Discovery and Technical Development to implement methods for biophysical characterization of biologics, epitope mapping, fermentanomics. Investigated fingerprinting methods for the characterization of biologics.

• Postdoctoral Fellow at Harvard University
  2004 - 2007 · 3 yrs

  Postdoc with Gerhard Wagner and Greg Verdine

• NMR Spectroscopist at New York Structural Biology Center
  2002 - 2004 · 2 yrs

• Postdoctoral Fellow at Clark University
  2000 - 2002 · 2 yrs

  Postdoc with Rafael Brüschweiler