Herk-de-Stad, Flemish Region, Belgium
I am a scientist specialising in neuroimmunology, with a strong focus on early target discovery and validation in complex neurological disorders. My work integrates iPSC-based platforms, advanced in vivo models, and multi-omics data to uncover and validate novel therapeutic targets. I lead cross-functional initiatives and contribute to the strategic direction of both internal programmes and external collaborations.
We established a whole-brain microscopic imaging platform to monitor the spreading of protein aggregates in mouse models for Alzheimer's Disease. This is done by a combination of state-of-the-art tissue clearing strategies, advanced light microscopy and 3D image informatics. - The Laboratory of Cell Biology and Histology, University of Antwerp. Prof. Dr. Winnok De Vos, Dr. Rony Nuydens, Prof. Dr. Jean-Pierre Timmermans.
We investigated the role of microtubule stability in the formation of neuronal networks in primary hippocampal cultures. This was done by challenging such cultures with microtubule-targeting drugs in an automated microscopic screening assay. - The Laboratory of Cell Biology and Histology, University of Antwerp. Prof. Dr. Jean-Pierre Timmermans.
Characterization of the photoelectric effect of LEDs on multi-electrode arrays. - The Laboratory of Theoretical Neurobiology and Neuroengineering, University of Antwerp, Prof. Dr. Giugliano.
Label-free optical microscopy of the cytoskeleton using second-harmonic generation in living cultured cells. - BIOMED, University of Hasselt, Prof. Dr. Ameloot.