Isabella Rosales Enriquez

MSc Experimental and Translational Immunology Student @ UCL | Amgen Scholar 2025 | Research in WAS, Malaria & HIV | Institut Pasteur · Karolinska Institutet

United Kingdom

About

Master’s student in Experimental and Translational Immunology at UCL, with knowledge of diverse laboratory techniques and driven to tackle neglected and complex diseases from Wiskott-Aldrich Syndrome to malaria and HIV. My research journey has taken me across three countries and three laboratories. Including Karolinska Institutet (twice), Institut Pasteur as an Amgen Scholar, and now at UCL where I've built hands-on expertise in flow cytometry, immunofluorescence, FACS, Western blotting, and computational tools like AlphaFold3 and R Studio. My experience across various roles has further developed my adaptability and passion, allowing me to dive deeper into biomedicine. I strive to improve my reflective and technical expertise, i'm currently working on structure-guided analysis of HIV neutralizing antibodies and preparing for a PhD, where I hope to contribute to the development of accessible treatments for neglected diseases.

Experience

  • Amgen Scholars Research Internship at Institut Pasteur
    Jul 2025 - Sep 2025 · 3 mos

    Investigated the immunogenicity of novel P. falciparum mRNA vaccine candidates in mouse models, contributing to the search for an effective malaria vaccine. Worked with the Malaria Parasite Biology and Vaccines Department. -Assessed antibody responses through isotyping, peptide binding, and growth inhibition assays using vaccinated mouse sera to identify immune correlates of protection -Tracked blood-stage parasite detection in sporozoite-challenged immunized mice using FACS -Conducted immunofluorescence assays to map antibody binding to sporozoites at the cellular level -Presented findings as a poster at the Amgen Scholars Symposium, University of Cambridge

  • Research Intern at Karolinska Institutet
    Jan 2025 - Jun 2025 · 6 mos

    Studied the therapeutic potential of a small molecule drug candidate to treat Wiskott-Aldrich Syndrome (WAS), contributing to a manuscript currently in preparation. -Designed and executed multicolor flow cytometry experiments to characterize platelet dynamics and dense granule release in WAS patient-derived samples -Built an end-to-end immunofluorescence confocal microscopy pipeline, from optimizing platelet isolation protocols to imaging and quantification in CellProfiler -Trained an AI image classifier in CellProfiler Analyst to automate morphological analysis of human platelets, reducing manual analysis time -Analyzed experimental data in R Studio and Prism; presented results at internal lab meetings -Participated in journal clubs on immunology topics, strengthening contextual understanding of the research

  • Research Internship at Karolinska Institutet
    Jul 2024 - Sep 2024 · 3 mos

    Investigated the nuclear localization of WASp, a cytoskeletal regulator mutated in Wiskott-Aldrich Syndrome in B-cells, building foundational expertise that directly informed later research in the same field. -Performed standard and co-immunoprecipitation Western blots on isolated nuclear and cytoplasmic lysates to detect and characterize WASp protein interactions -Analyzed B-cell differentiation and class switch recombination (CSR) capacity across mouse models carrying XLN-associated WASp mutations using multicolor flow cytometry -Confirmed mouse model genotypes via Southern blot and maintained B-cell cultures throughout the project Resulted in coming back as an Erasmus Research Intern in 2025