Dallas-Fort Worth Metroplex
-Chemistry PhD with 10+ years of pharmaceutical and food industrial R&D experience in sample analysis, formulation and synthesis. Familiar with working in GLP, GMP, BSL2 and DEA-regulated labs. -US green card holder, no work sponsorship required.
• Use HPLC, LCMS, GCMS and enzymatic assays to develop new analytical methods to qualitatively and quantitatively monitor protein profile changes and flavor compounds formations during dairy product fermentation and shelf-life studies. • Optimize original analysis procedures to improve method accuracy. In one example, the analysis method error was minimized to <20% of its original value after optimization. • Support the company’s bench-top, pilot or full scale product manufacturing by leading small chemistry teams to perform different dairy chemistry experiments to compare different batches of materials and analyze key factors for sample texture, flavor and yield. • Train lab members with new sample analysis methods and help them troubleshoot their experiments. • Maintain and calibrate the lab instruments. Prepare and revise SOPs for different experiments.
-Synthesize highly pure isotope-labeled compounds as reference standards for biopharmaceutical assays in a timely manner. Target molecules include vitamins, environmental contaminants, drugs, drug metabolites, and drug contaminants etc. -Develop, validate and review GLP analytical methods to provide Certificate of Analysis for customized samples. Analytical techniques include NMR, LCMS, GCMS, HPLC, optical rotation and Karl Fischer etc. -Interpret and document experimental results following the SOP guideline -Support laboratory equipment maintenance and validation
Study the chemistry and biochemistry of antibiotic and anticancer natural products using a combination of organic synthesis and analytic chemistry methods. Coauthor of one Science and two J. Am. Chem. Soc research papers as more publications are in preparation. ------------------------------------------------------------- Key Projects: Mechanistic studies of the epoxidase involved in biosynthesis of the antibiotic fosfomycin -Developed analytical methods to monitor the complicated enzymatic transformation process based on a combination of techniques including NMR, MS, and HPLC etc. -Synthesized and tested a range of compounds as substrate analogs to probe the enzyme reaction mechanism and characterize products of each conversion Biosynthesis studies of marine natural product kijanimicin -Led the project team by setting up task force and monitoring project progress -Accomplished a 20-step chemical synthesis of a kijanimicin biosynthetic intermediate -Extracted and purified kijanimicin from fermentation culture and isolated different kijanimicin hydrolysis products
-Coached new lab members by building up their experimental skills and guiding them in research project design -Developed concise and high-yield synthetic routes to hydroxyltetraphenylenes -Explored self-assembly of supramolecular constructions with tetraphenylene-based building blocks -Determined the inversion barrier of tetraphenylene which had been a topic of argument for more than 30 years