Bethesda, Maryland, United States
I am a clinical fellow in hematopathology, with interests in clinical diagnosis and research in leukemias and lymphomas. With a bioinformatic background, I am inspired to integrate patient care, genomic, and clinical trials to advance the understanding and outcome of hematological malignancies, especially acute myeloid leukemia and chronic myeloid neoplasms.
Project Leader: • Proposed and published desired features (desiderata) of common query representation models in electronic health records (EHR)-driven identification of research subjects for genetic and clinical studies o Coauthored with 30+ prominent scientists from 12 leading institutes across 3 national research networks • Developed 2 only-solutions to execute artifacts in National Quality Forum (NQF)-sponsored Quality Data Model (QDM) in existing EHR databases (Part of PhEMA) o Adapted a new platform that is popular in data-mining community (KNIME) to be the key component of the solutions o Awarded with 2015 AMIA Distinguished CRI Paper Award: “… that contributes to the state of knowledge and practice, is novel, and will impact future work through dissemination” • Exploring 5+ medical or genetic risk factors of clinical vitamin B12 deficiency o Identified ~3,000 cases and ~10,000 controls from Vanderbilt EHR database o Replicated Lam et al.’s 2013 JAMA publication in a different clinical setting o Developed transportable and executable KNIME workflows to facilitate collaborations with other institutes (e.g., Northwestern University) • Exploring the roles of the G6PC2 variation in blood glucose control using EHR data o Determined that the variation only affects blood glucose levels within the normal range, but not those of elevated levels o Suggested that the variation may be related to hypoglycemia, a serious clinical condition • Integrating PhEMA tools and PheWAS (a Vanderbilt platform) to i2b2 (a nation-wide popular EHR data warehouse system) • Reviewed 5+ manuscripts for JAMIA, AMIA conferences, and PLOS One Team Projects: • Representing Vanderbilt team in PhEMA project, a collaboration with teams from the Mayo Clinic and Northwestern University • Promoting interoperability of Vanderbilt EHR infrastructure • Coordinated three clinical fellows’ EHR-based projects, mentored two intern, and provided orientation to two new team members
• Analyzed computationally and statistically next generation sequencing and microarray data • Developed de novo data analytic tools for high throughput platforms (especially in epigenomics) • Provide medical consultations for 2 engineering and modeling projects • Performed laboratory experiments, including: DNA/RNA extraction, PCR, RT-PCR • Taught four semesters in Genetics Labs and Introduction to Life Sciences