Singapore, Singapore
I am a Year 4 Biological Science undergraduate with strong interests in molecular and cell biology, cancer immunotherapy, and cell & gene therapy research. I am highly motivated to pursue translational biomedical research and am actively seeking opportunities to deepen my knowledge and gain hands-on experience in these areas. My academic training and laboratory experiences have strengthened my foundation in biological sciences and cultivated a deep interest in cancer & stem cell research, particularly in the development of next-generation cancer immunotherapy. My early exposure to scientific research through the16th Elementz Science Project Competition and Exhibition and the Scientific Programme 2017 first sparked my curiosity in research and introduced me to scientific writing, experimental design and collaborative problem-solving. During my undergraduate studies in NTU, I had the opportunity to undertake URECA Project over 2 years and continued my Final Year Project from my internship experience. These opportunities allowed me to gain deeper exposure to research and further confirmed my passion for pursuing a career in immunology and cancer research. Through these experiences, I developed hands-on skills in mammalian cell culturing, molecular cloning, staining, FlowJo analysis, lentivirus production, feeder-based CAR-NK cell expansion and stem cell differentiation. I am particularly passionate about understanding how the immune system can be engineered to combat cancer and how translational research can bridge fundamental discoveries with clinical applications. I am eager to contribute to research that advances innovative therapies and improves patient outcomes. I value continuous learning, collaboration and scientific curiosity, and I would be delighted to connect with researchers and professionals in the field of immunology, cancer biology and cell & gene therapy to explore opportunities for collaboration and growth.
Supervisors: Assoc Professor Andy Tan & Dr Chelsia Wang Project Title: Feeder-based production of human natural killer (NK) cells engineered with chimeric antigen receptors (CARs) for solid tumour immunotherapy - Grade: A+ - Transduced hPBMC-derived NK cells with CAR - Evaluated possibility of improving transduction efficiency of CAR into NK cells - Evaluated feasibility of CAR-NK cells expansion and function in stirred tank reactor (STR) using in-house generated eFCs
Supervisors: Assoc Professor Andy Tan & Dr Chelsia Wang Project Title: Clonal selection and characterization of feeder cells to support manufacturing of natural killer (NK) cells for cancer immunotherapy - Expanded hPBMC-derived NK cells using in-house engineered feeder cells (eFCs) - Tested cytotoxicity of NK cells expanded with eFCs for cancer immunotherapy - Generated in-house eFCs for NK cell expansion
Supervisors: Assoc Professor Christine Cheung & Dr See Jia Xiang Project Title: Crosstalk between endothelial cells and adaptive immune system in metabolic dysfunction-associated steatotic liver disease - Explored the role of liver endothelial cells as antigen-presenting cells in the context of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) - Generated hPSC-derived liver sinusoidal endothelial cells (LSECs) by differentiating hPSCs into vein endothelial cells (VECs) and into LSECs - Gained proficiency in mammalian cell culture, stem cell differentiation, staining and using FlowJo software to analyze FACS data
Supervisors: Professor Laurent Rénia & Dr Goh Yun Shan Mentors: Loh Chiew Yee (Cheryl) & Hor Pei Xiang Project Title: Development of serological assay against seasonal coronaviruses - Investigated how antibody response to SARS-CoV-2 might be affected by pre-existing immunity towards other HCoVs and develop a serological assay against seasonal HCoVs for antibody analysis - Created lentivirus and S protein-expressing cells for seasonal coronaviruses via transfection and transduction respectively - Gained proficiency in mammalian cell culturing, molecular cloning, staining and using FlowJo software to analyse cytoFLEX data
- Assisted in sending and fetching of patients to and fro wards and operation theatre - Handled beds for patients going for operation - Inspected specimens - Initiated to teach new staff members about ferry team job on their first day
- Certified in Caregiver Basic skills (CGT) and CPR-AED skills - Assisted elderly in activities of daily living (ADLs) such as personal care & hygiene, companionship, light housekeeping, medication reminders, medical escort, toileting, check-in visits and staying active - Handled care recipients with care as stated by instructions given by care owners or partner organisations - Adapted to the various living conditions of the elderly to assist in their ADLs