Ann Arbor, Michigan, United States
PhD Student at University of Michigan | Clinical Pharmacology and Drug Development I am a Clinical Pharmacy Translational Science PhD student at the University of Michigan, dedicated to advancing precision medicine through pharmacometrics, pharmacogenomics and morphomics. My work focuses on bridging the gap between complex data and clinical application to optimize drug therapy and patient outcomes. With a background as a Research Fellow at UCSF and an MS in Pharmaceutical Sciences from the University at Buffalo, I have developed skills in: 1. Pharmacokinetic Modeling: Population PK (PopPK) and Physiologically Based Pharmacokinetic (PBPK) modeling using tools like NONMEM, PK-Sim, and Phoenix WinNonlin. 2. Disease Area Expertise: Extensive research in HIV/AIDS, immunotherapy, and drug-drug interactions (DDIs). 3. Data Science: Utilizing R and pharmacometric modeling to analyze real-world evidence and clinical trial data. I am passionate about using quantitative signatures to understand disease progression and drug disposition, particularly in underserved or complex patient populations. I always try seeking innovative ways to make drug development more efficient and effective. Technical Toolkit: NONMEM | R | PK-Sim | Phoenix WinNonlin | Monolix | Clinical Trial Design
Mentor: Dr. Amelia Deitchman 1. Conducted a comprehensive population pharmacokinetic assessment of sirolimus and antiretroviral therapies in non-transplant recipients with HIV. 2. Developed a pharmacodynamic model to predict viral rebound during analytic treatment interruption phase in individuals receiving broadly neutralizing antibodies. 3. Facilitated an HIV clinical trial design and protocol. 4. Developed and validated an LC-MS/MS method for quantifying tenofovir-dp and emtricitabine-tp in PBMC and tissue samples. 5. Analyzed and devised a PKPD model to inform PD-1 receptor occupancy in a Phase I nivolumab trial for people with HIV.
Part of PharmD curriculum. 1. Participated in the hospital ward rounds at clinical nephrology and palliative care units, collaborating with physicians to optimize patient outcomes. 2. Identified and managed adverse drug reactions and drug-drug interactions, ensuring safe and effective medication use. 3. Provided evidence-based recommendations to physicians on new drug therapies, utilizing up-to-date clinical knowledge and drug information resources. 4. Assisted physicians with accurate dosing calculations, applying pharmacokinetic principles and drug monitoring techniques. 5. Conducted patient counseling sessions, promoting medication adherence and educating patients on the appropriate use of their medications.