Guido Mathews

Vice President Innovation | Artificial Intelligence Research | Life Sciences | Medical Devices | Pharmaceuticals | Biopharmaceuticals | Digital Health | Expert in AI-enabled biomedical innovation

Berlin Metropolitan Area

About

As a business development and go-to-market leader with over two decades in pharmaceuticals, healthcare AI, and life sciences, I have built and scaled enterprise AI platforms, data platforms, and digital diagnostics businesses from concept through global commercial adoption. My expertise spans platform commercialization, AI strategy, regulatory affairs, and ecosystem orchestration, combined with full P&L ownership and executive leadership in regulated MedTech and biopharma environments. At Bayer Pharmaceuticals as Vice President and Head of the Center of Excellence for Imaging, Data and AI Research, I co-led the definition and execution of the enterprise AI strategy across R&D, Clinical Development, and Commercial functions. I founded and scaled the Bayer AI Innovation Platform as a global execution engine for agentic AI and ML workflows and enterprise data platforms. I built and governed a global partnership ecosystem spanning hyperscalers, hospital networks, and AI startups, serving as primary executive liaison to frontier AI partners and identifying high-impact integration points for generative AI across R&D and commercial workflows. I mobilized a top-tier innovation consortium securing selection for the ARPA-H INDEX program, positioning the organization at the forefront of AI-enabled biomedical innovation. As Vice President and Head of Digital Diagnostics, I held full P&L accountability for a global digital diagnostics software and service portfolio, driving enterprise adoption across more than a thousand customer deployments. I rebuilt and scaled Centafore into a revenue-generating medical imaging core lab and CRO services provider. I co-developed, launched, and scaled Calantic Digital Solutions, a global AI marketplace for radiology and imaging. I led the global scale-up of Radimetrics, an enterprise-grade analytics platform embedded in mission-critical, regulated clinical workflows. My approach combines go-to-market execution, commercial strategy, and regulatory expertise across GxP, SaMD, and FDA engagement with strategic partnerships and alliance management. I bring deep experience in business transformation, innovation management, and cross-functional leadership bridging science, operations, and commercial priorities in healthcare and digital health.

Experience

  • Healthcare, AI and Data Ecosystems at Phinomics
    2026 - Present · 6 mos

  • Healthcare, AI and Data Ecosystems at Haize Labs
    2026 - Present · 6 mos

  • Bayer (13 yrs 1 mo)
    • Vice President Imaging, Data and AI | Biopharma | Pharmaceuticals
      2022 - 2025 · 3 yrs

      As a Vice President and Head of the Center of Excellence for Imaging, Data and AI Research, I co-led the definition and execution of the enterprise AI strategy across R&D, Clinical Development, and Commercial functions within the pharmaceuticals and biopharma sector. I translated strategic priorities into platform investments, operating models, and scalable go-to-market execution for healthcare AI and data platforms. I founded and scaled the AI Innovation Platform as a global execution engine for agentic AI, ML workflows, and enterprise data platforms serving research and commercial use cases. I built and governed a global partnership ecosystem spanning hyperscalers, hospital networks, academic institutions, and AI startups. I served as primary executive liaison to frontier AI partners, identifying high-impact integration points for generative AI across R&D, regulatory affairs, and commercial workflows. I mobilized a top-tier innovation consortium securing selection for the ARPA-H INDEX program, positioning the organization at the forefront of AI-enabled biomedical innovation. I drove regulatory and operating model leadership across GxP compliance and SaMD frameworks. I established strategic partnerships with cross-functional leadership across business development, digital transformation, and innovation management to position the company among the most AI-ready pharmaceutical organizations globally in the healthcare and life sciences space.

    • Vice President Digital Diagnostics | Digital Health | Medical Devices | Pharmaceuticals
      2017 - 2022 · 5 yrs

      As a Vice President and Head of Digital Diagnostics, I held full P&L accountability for a global digital diagnostics software and service portfolio within the pharmaceuticals and medical devices sector. I drove platform commercialization and enterprise sales adoption across a large-scale global customer base, building the business from pilot deployments to widespread enterprise adoption in radiology and diagnostic imaging. I rebuilt and scaled Centafore into a revenue-generating medical imaging core lab and CRO services provider, establishing commercial excellence in clinical imaging operations. I co-developed, launched, and scaled Calantic Digital Solutions as a global AI marketplace for radiology, creating a SaaS platform connecting AI startups with hospital networks and healthcare institutions. I led the global scale-up of Radimetrics, an enterprise-grade analytics platform embedded in mission-critical, regulated clinical workflows across healthcare and MedTech environments. I drove strategic alliances and M&A enablement across the digital health and AI platforms landscape. I secured FDA Breakthrough Device Designation through co-development of AI solutions with hyperscalers and academic partners, demonstrating regulatory expertise across GxP, SaMD, and FDA engagement. I established the Bayer LifeHub innovation ecosystem in the UK, building strategic partnerships connecting biopharma, AI startups, and academic research to accelerate pipeline management and product strategy in life sciences.

    • Head of Operations Governance & Support | Pharmaceuticals
      2014 - 2017 · 3 yrs

      As a Head of Operational Governance and Support, I led governance frameworks and operational support functions for the pharmaceutical division, ensuring compliance management and process optimization across business operations. I established standardized governance processes bridging cross-functional teams in regulatory affairs, commercial operations, and portfolio management. I drove change management initiatives and business transformation efforts to improve operational excellence and organizational agility. I developed business case development methodologies and risk assessment frameworks supporting strategic planning decisions. I coordinated stakeholder engagement across senior leadership to align governance priorities with enterprise objectives in the pharmaceuticals and life sciences sector. I contributed to digital transformation and vendor management programs supporting healthcare and biopharma operations.