Italy
Leading a global wet-and-dry discovery team, comprising Next Generation Sequencing labs, single cell genomics labs, a data science team and project managers. Having a central role in the Novartis organization, we collaborate in a global matrix environment with a diverse group of scientists in the disease areas (e.g., autoimmunity transplantation and inflammation, respiratory, cardiovascular, oncology, neuroscience, musculoskeletal, infectious and tropical diseases, among others) to develop and apply new analysis tools to drug discovery and preclinical studies.
Leading a technology focused team dedicated to advancing target discovery and therapeutic development by discovering differentially regulated pathways, targets and biomarkers. Working at the interface between technology, informatics, and research. Key expertise (genomics and proteomics): Next generation Sequencing (NGS), Mass cytometry (CyTOF), bioinformatics, data analysis, computational biology.
Bioinformatics, statistics, data analysis, and scientific software development in support of the research projects of CRG, PRBB, and external groups Organized periodical courses to train biologists on bioinformatics Started-up and led the Bioinformatics Unit (6 members, including me) for 2 years; President of the ITC commission, and co-lead of the team of scientific system administrators (3 members) Contributed with the team to ~60 research projects by providing expertise in programming, experimental design, and advanced data analysis, focusing primarily on high-throughput genomics technologies (including microarrays, genotyping, and next-generation sequencing), with some involvement in proteomics (SILAC, ProteoWiki sample tracking system)
biomarker projects microarray analysis, functional analysis, data management, software implementation and development, IQ/OQ validation, SOPs & WIs writing for defining data management workflow among different laboratories, sequence/genomic analyses tight collaboration with IT, QA, pharmacologists, biomarker scientists, and bioinformatics colleagues
• Development of project-specific relational databases, and biologist oriented resources (Roma G. et al, Nucleic Acids Research 2008; Sanseverino W.*, Roma G.*, et al., Nucleic Acids Research 2010); • Research on large scale identification of novel genes (Roma G. et al, Genome Research 2007); • Research on large-scale functional genomics datasets analysis (Sardiello M. et al., Human Molecular Genetics 2005). • Set-up and maintenance of bioinformatics tools and genome browsers (e.g. Ensembl databases)